Forfeited hepatogenesis program and increased embryonic stem cell traits in young hepatocellular carcinoma (HCC) comparing to elderly HCC

• Published in: BMC genomics Vol. 14; no. 1; p. 736
• Main Authors: Wang, Hsei-Wei, Hsieh, Tsung-Han, Huang, SSu-Yi, Chau, Gar-Yang, Tung, Chien-Yi, Su, Chien-Wei, Wu, Jaw-Ching
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2013; BioMed Central
• Subjects: Adult; Antibodies; Antigens; Carcinogenesis - genetics; Carcinoma, Hepatocellular - etiology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - pathology; Cohort Studies; Comparative analysis; Comparative Genomic Hybridization; Development and progression; DNA replication; Embryonic Stem Cells - metabolism; Female; Gene expression; Gene Regulatory Networks; Genetic aspects; Hepatitis; Hepatitis B Surface Antigens - blood; Hepatitis B virus; Hepatitis C Antibodies - blood; Hepatoma; Humans; Liver cancer; Liver cirrhosis; Liver Neoplasms - etiology; Liver Neoplasms - genetics; Liver Neoplasms - pathology; Male; Medical research; Middle Aged; Neoplasm Staging; Neoplastic processes; Stem cells; Transcriptome; Tumors; Taiwan
• ISSN: 1471-2164; 1471-2164
• DOI: 10.1186/1471-2164-14-736

Hepatocellular carcinoma (HCC) in young subjects is rare but more devastating. We hypothesize that genes and etiological pathways are unique to young HCC (yHCC; ≤ 40 years old at diagnosis) patients. We therefore compared the gene expression profiles between yHCCs and HCCs from elderly patients. All...