High levels of T lymphocyte activation in Leishmania-HIV-1 co-infected individuals despite low HIV viral load

• Published in: BMC infectious diseases Vol. 10; no. 1; p. 358
• Main Authors: Santos-Oliveira, Joanna R, Giacoia-Gripp, Carmem B W, Alexandrino de Oliveira, Priscilla, Amato, Valdir S, Lindoso, Jose Ângelo L, Goto, Hiro, Oliveira-Neto, Manoel P, Mattos, Marise S, Grinsztejn, Beatriz, Morgado, Mariza G, Da-Cruz, Alda M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.12.2010; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; ADP-ribosyl Cyclase 1 - analysis; Adult; AIDS; Americas; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes - chemistry; Comorbidity; Female; HIV; HIV infection; HIV Infections - complications; HIV Infections - immunology; HIV Infections - virology; HIV-1; Human immunodeficiency virus; Humans; Leishmaniasis; Leishmaniasis - complications; Leishmaniasis - immunology; Lymphocyte transformation; Lymphocytes; Male; Middle Aged; Parasitic diseases; Physiological aspects; Studies; T cells; T-Lymphocytes - immunology; Viral Load; Brazil

Concomitant infections may influence HIV progression by causing chronic activation leading to decline in T-cell function. In the Americas, visceral (AVL) and tegumentary leishmaniasis (ATL) have emerged as important opportunistic infections in HIV-AIDS patients and both of those diseases have been i...