Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil

• Published in: BMC infectious diseases Vol. 11; no. 1; p. 247
• Main Authors: Mendes-Correa, Maria Cassia, Pinho, João R R, Gomes-Gouvea, Michele S, da Silva, Adriana C, Guastini, Cristina F, Martins, Luiz G, Leite, Andréa G, Silva, Mariliza H, Gianini, Reinaldo J, Uip, David E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2011; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; Adenine - administration & dosage; Adenine - analogs & derivatives; Adult; AIDS; Alanine Transaminase - blood; Anti-HIV Agents - administration & dosage; Antiretroviral drugs; Antiretroviral Therapy, Highly Active - methods; Brazil; Brazil - epidemiology; CD4 Lymphocyte Count; Cross-Sectional Studies; Development and progression; Drug therapy; Female; Health aspects; Hepatitis; Hepatitis B; Hepatitis B e Antigens - blood; hepatitis B virus; Hepatitis B virus - isolation & purification; Hepatitis B, Chronic - diagnosis; Hepatitis B, Chronic - epidemiology; Highly active antiretroviral therapy; HIV; HIV infection; HIV Infections - complications; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Male; Middle Aged; Mortality; Organophosphonates - administration & dosage; Retrospective Studies; Risk Factors; Tenofovir; Viral Load; Viremia - epidemiology; virological outcome; Brazil

HBV-HIV co-infection is associated with an increased liver-related morbidity and mortality. However, little is known about the natural history of chronic hepatitis B in HIV-infected individuals under highly active antiretroviral therapy (HAART) receiving at least one of the two drugs that also affec...