Fr-TM-align: a new protein structural alignment method based on fragment alignments and the TM-score

• Published in: BMC bioinformatics Vol. 9; no. 1; p. 531
• Main Authors: Pandit, Shashi Bhushan, Skolnick, Jeffrey
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 12.12.2008; BioMed Central; BMC
• Subjects: Algorithms; Animals; Computational biology; Computational Biology - methods; Computers; Databases, Protein; Humans; Methodology; Models, Statistical; Molecular Sequence Data; Protein Conformation; Protein Structure, Tertiary; Proteins; Proteins - chemistry; Sequence Alignment - methods; Sequence Analysis, Protein - methods; Software; Structure; United States

Protein tertiary structure comparisons are employed in various fields of contemporary structural biology. Most structure comparison methods involve generation of an initial seed alignment, which is extended and/or refined to provide the best structural superposition between a pair of protein structu...