Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging

• Published in: Current medicinal chemistry Vol. 23; no. 18; p. 1818
• Main Author: Pike, Victor W
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2016
• Subjects: Brain - diagnostic imaging; Brain - metabolism; Humans; Ligands; Neuroimaging - methods; Positron-Emission Tomography - methods; Proteins - metabolism; Radioisotopes - metabolism

The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and...