Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging
The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and...
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| Published in | Current medicinal chemistry Vol. 23; no. 18; p. 1818 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United Arab Emirates
01.01.2016
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| Subjects | |
| Online Access | Get more information |
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| Abstract | The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets. |
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| AbstractList | The development of reversibly binding radioligands for imaging brain proteins in vivo, such as enzymes, neurotransmitter transporters, receptors and ion channels, with positron emission tomography (PET) is keenly sought for biomedical studies of neuropsychiatric disorders and for drug discovery and development, but is recognized as being highly challenging at the medicinal chemistry level. This article aims to compile and discuss the main considerations to be taken into account by chemists embarking on programs of radioligand development for PET imaging of brain protein targets. |
| Author | Pike, Victor W |
| Author_xml | – sequence: 1 givenname: Victor W surname: Pike fullname: Pike, Victor W email: pikev@mail.nih.gov organization: Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Rm. B3C346A, 10 Center Drive, Bethesda, MD 20892, USA. pikev@mail.nih.gov |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27087244$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Brain - diagnostic imaging Brain - metabolism Humans Ligands Neuroimaging - methods Positron-Emission Tomography - methods Proteins - metabolism Radioisotopes - metabolism |
| Title | Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging |
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