LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells

• Published in: BMC cancer Vol. 13; no. 1; p. 501
• Main Authors: Harrison, Susan MW, Knifley, Teresa, Chen, Min, O’Connor, Kathleen L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.10.2013; BioMed Central
• Subjects: Actin; Actins - metabolism; Analysis; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cancer cells; Cell adhesion & migration; Cell Line, Tumor; Cell Movement; Colleges & universities; Cytoskeleton; Development and progression; Epidermal growth factor; Epidermal Growth Factor - metabolism; Female; Hepatocyte Growth Factor - metabolism; Humans; Kinases; Lysophospholipids - metabolism; Mitogen-Activated Protein Kinases - metabolism; Motility; Myosin-Light-Chain Kinase - metabolism; Myosins - metabolism; Neoplasm Invasiveness; Phosphorylation; Physiological aspects; Polymerization; Proteins; rac GTP-Binding Proteins - metabolism; rho GTP-Binding Proteins - metabolism; Signal Transduction; United States

Various pathways impinge on the actin-myosin pathway to facilitate cell migration and invasion including members of the Rho family of small GTPases and MAPK. However, the signaling components that are considered important for these processes vary substantially within the literature with certain path...