Human periprostatic adipose tissue promotes prostate cancer aggressiveness in vitro

• Published in: Journal of experimental & clinical cancer research Vol. 31; no. 1; p. 32
• Main Authors: Ribeiro, Ricardo, Monteiro, Cátia, Cunha, Virgínia, Oliveira, Maria José, Freitas, Mariana, Fraga, Avelino, Príncipe, Paulo, Lobato, Carlos, Lobo, Francisco, Morais, António, Silva, Vítor, Sanches-Magalhães, José, Oliveira, Jorge, Pina, Francisco, Mota-Pinto, Anabela, Lopes, Carlos, Medeiros, Rui
• Format: Journal Article
• Language: English
• Published: England BioMed Central 02.04.2012; BioMed Central Ltd; BMC
• Subjects: Adipose tissue; Adipose Tissue - enzymology; Adipose Tissue - pathology; Aged; Aggressiveness; Body fat; Cell line; Cell Proliferation; Cell tracking; Culture Media, Conditioned; Humans; In Vitro Techniques; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Medical research; Obesity; Obesity - pathology; Oncology; Periprostatic; Prostate cancer; Prostatic Neoplasms - enzymology; Prostatic Neoplasms - pathology; Rodents

Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggre...