Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade

• Published in: BMC cancer Vol. 13; no. 1; p. 327
• Main Authors: Yung, Mingo Ming Ho, Chan, David Wai, Liu, Vincent Wing Sun, Yao, Kwok-Ming, Ngan, Hextan Yuen-Sheung
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 03.07.2013; BioMed Central
• Subjects: Analysis; Blotting, Western; Cell growth; Cell Line, Tumor; Cervical cancer; Female; Forkhead Box Protein M1; Forkhead Box Protein O3; Forkhead Transcription Factors - metabolism; Growth; Humans; Kinases; Physiological aspects; Plasmids; Protein kinases; Protein Kinases - metabolism; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - physiology; Transfection; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Hong Kong
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/1471-2407-13-327

Although advanced-stage cervical cancer can benefit from current treatments, approximately 30% patients may fail after definitive treatment eventually. Therefore, exploring alternative molecular therapeutic approaches is imperatively needed for this disease. We have recently shown that activation of...