Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

• Published in: Skeletal muscle Vol. 1; no. 1; p. 11
• Main Authors: Fry, Christopher S, Drummond, Micah J, Glynn, Erin L, Dickinson, Jared M, Gundermann, David M, Timmerman, Kyle L, Walker, Dillon K, Dhanani, Shaheen, Volpi, Elena, Rasmussen, Blake B
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.03.2011; BioMed Central; BMC
• Subjects: Care and treatment; Cellular signal transduction; Falls (Accidents); Health aspects; Protein biosynthesis; Rapamycin; Risk factors; Sarcopenia; United States

Sarcopenia, the loss of skeletal muscle mass during aging, increases the risk for falls and dependency. Resistance exercise (RE) training is an effective treatment to improve muscle mass and strength in older adults, but aging is associated with a smaller amount of training-induced hypertrophy. This...