Nonsynonymous Synonymous Variants Demand for a Paradigm Shift in Genetics

• Published in: Current genomics Vol. 24; no. 1; pp. 18 - 23
• Main Author: Vihinen, Mauno
• Format: Journal Article
• Language: English
• Published: United Arab Emirates Bentham Science Publishers 01.01.2023; Benham Science Publishers
• Subjects: Annotations; Biologi; Biological Sciences; distribution of fitness effects; Evolution; Evolutionary Biology; Evolutionsbiologi; Genetic diversity; Genetics; Mathematical analysis; mRNA; Natural Sciences; Naturvetenskap; nonsynonymous- to-synonymous substitution ratio; phylogenetics; Phylogeny; Principles; Proteins; silent variation; Stop codon; Synonymous variation; Systematics; unsense variation; silent variation; phylogenetics; unsense variation; distribution of fitness effects; nonsynonymous-to-synonymous substitution ratio; Synonymous variation

Synonymous (also known as silent) variations are by definition not considered to change the coded protein. Still many variations in this category affect either protein abundance or properties. As this situation is confusing, we have recently introduced systematics for synonymous variations and those...