Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers
The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how s...
Saved in:
Published in | Neural development Vol. 2; no. 1; p. 26 |
---|---|
Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
BioMed Central Ltd
03.12.2007
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises.
Using a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an increase in proliferation and inward thickening of the granule cell precursors, which likely causes an associated slight invagination of the Purkinje cell layer. Thereafter, granule cell precursors within anchoring centers become distinctly elongated along the axis of the forming fissure. As the outer cerebellar surface begins to fold inwards, Bergmann glial fibers radiate in towards the base of the immature fissure in a fan shape. Once the anchoring center is formed, outgrowth of folia seems to proceed in a self-sustaining manner driven by granule cell migration along Bergmann glial fibers. Finally, by analyzing a cerebellum foliation mutant (Engrailed 2), we demonstrate that changing the timing of anchoring center formation leads to predictable changes in the shape and size of the surrounding folia.
We present a new cellular model of the initial formation of cerebellar fissures with granule cells providing the driving physical force. Both the precise timing of the appearance of anchoring centers at the prospective base of each fissure and the subsequent coordinated action of granule cells and Bergmann glial fibers within the anchoring centers dictates the shape of the folia. |
---|---|
AbstractList | The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises.
Using a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an increase in proliferation and inward thickening of the granule cell precursors, which likely causes an associated slight invagination of the Purkinje cell layer. Thereafter, granule cell precursors within anchoring centers become distinctly elongated along the axis of the forming fissure. As the outer cerebellar surface begins to fold inwards, Bergmann glial fibers radiate in towards the base of the immature fissure in a fan shape. Once the anchoring center is formed, outgrowth of folia seems to proceed in a self-sustaining manner driven by granule cell migration along Bergmann glial fibers. Finally, by analyzing a cerebellum foliation mutant (Engrailed 2), we demonstrate that changing the timing of anchoring center formation leads to predictable changes in the shape and size of the surrounding folia.
We present a new cellular model of the initial formation of cerebellar fissures with granule cells providing the driving physical force. Both the precise timing of the appearance of anchoring centers at the prospective base of each fissure and the subsequent coordinated action of granule cells and Bergmann glial fibers within the anchoring centers dictates the shape of the folia. Abstract Background The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises. Results Using a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an increase in proliferation and inward thickening of the granule cell precursors, which likely causes an associated slight invagination of the Purkinje cell layer. Thereafter, granule cell precursors within anchoring centers become distinctly elongated along the axis of the forming fissure. As the outer cerebellar surface begins to fold inwards, Bergmann glial fibers radiate in towards the base of the immature fissure in a fan shape. Once the anchoring center is formed, outgrowth of folia seems to proceed in a self-sustaining manner driven by granule cell migration along Bergmann glial fibers. Finally, by analyzing a cerebellum foliation mutant (Engrailed 2), we demonstrate that changing the timing of anchoring center formation leads to predictable changes in the shape and size of the surrounding folia. Conclusion We present a new cellular model of the initial formation of cerebellar fissures with granule cells providing the driving physical force. Both the precise timing of the appearance of anchoring centers at the prospective base of each fissure and the subsequent coordinated action of granule cells and Bergmann glial fibers within the anchoring centers dictates the shape of the folia. BACKGROUND: The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises. RESULTS: Using a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an increase in proliferation and inward thickening of the granule cell precursors, which likely causes an associated slight invagination of the Purkinje cell layer. Thereafter, granule cell precursors within anchoring centers become distinctly elongated along the axis of the forming fissure. As the outer cerebellar surface begins to fold inwards, Bergmann glial fibers radiate in towards the base of the immature fissure in a fan shape. Once the anchoring center is formed, outgrowth of folia seems to proceed in a self-sustaining manner driven by granule cell migration along Bergmann glial fibers. Finally, by analyzing a cerebellum foliation mutant (Engrailed 2), we demonstrate that changing the timing of anchoring center formation leads to predictable changes in the shape and size of the surrounding folia. CONCLUSION: We present a new cellular model of the initial formation of cerebellar fissures with granule cells providing the driving physical force. Both the precise timing of the appearance of anchoring centers at the prospective base of each fissure and the subsequent coordinated action of granule cells and Bergmann glial fibers within the anchoring centers dictates the shape of the folia. BACKGROUNDThe cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad platform on which the anterior-posterior organization of the sensory-motor circuits of the cerebellum are built, it is important to understand how such complex morphology arises. RESULTSUsing a combination of genetic inducible fate mapping, high-resolution cellular analysis and mutant studies in mouse, we demonstrate that a key event in initiation of foliation is the acquisition of a distinct cytoarchitecture in the regions that will become the base of each fissure. We term these regions 'anchoring centers'. We show that the first manifestation of anchoring centers when the cerebellar outer surface is smooth is an increase in proliferation and inward thickening of the granule cell precursors, which likely causes an associated slight invagination of the Purkinje cell layer. Thereafter, granule cell precursors within anchoring centers become distinctly elongated along the axis of the forming fissure. As the outer cerebellar surface begins to fold inwards, Bergmann glial fibers radiate in towards the base of the immature fissure in a fan shape. Once the anchoring center is formed, outgrowth of folia seems to proceed in a self-sustaining manner driven by granule cell migration along Bergmann glial fibers. Finally, by analyzing a cerebellum foliation mutant (Engrailed 2), we demonstrate that changing the timing of anchoring center formation leads to predictable changes in the shape and size of the surrounding folia. CONCLUSIONWe present a new cellular model of the initial formation of cerebellar fissures with granule cells providing the driving physical force. Both the precise timing of the appearance of anchoring centers at the prospective base of each fissure and the subsequent coordinated action of granule cells and Bergmann glial fibers within the anchoring centers dictates the shape of the folia. |
Audience | Academic |
Author | Sudarov, Anamaria Joyner, Alexandra L |
AuthorAffiliation | 1 Department of Cell Biology, New York University School of Medicine, 1st Avenue, NY, NY 10016, USA 2 Developmental Biology Program, Sloan-Kettering Institute, York Avenue, New York, NY 10021, USA |
AuthorAffiliation_xml | – name: 2 Developmental Biology Program, Sloan-Kettering Institute, York Avenue, New York, NY 10021, USA – name: 1 Department of Cell Biology, New York University School of Medicine, 1st Avenue, NY, NY 10016, USA |
Author_xml | – sequence: 1 givenname: Anamaria surname: Sudarov fullname: Sudarov, Anamaria email: sudarova@mskcc.org organization: Developmental Biology Program, Sloan-Kettering Institute, York Avenue, New York, NY 10021, USA. sudarova@mskcc.org – sequence: 2 givenname: Alexandra L surname: Joyner fullname: Joyner, Alexandra L |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18053187$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kstr3DAQh01JaR7ttcdiKBRycCrJsiz3UFiWPhYChT7OYiSPvQq2tZXk0vz3lbNLmqUpOmiY-c3HvM6zk8lNmGUvKbmiVIq3tOZNISnhBSuYeJKd3TtOHtin2XkIN4RUhAn5LDulklQllfVZZtboUeMwzGM-Or_buh4nDDa8y-MW884NFqJ1U76DGNFPuQ2582aLIXqI2Ob6Nh_nIdrCLJABfA6T2Tpvpz43OKWc8Dx72sEQ8MXhv8h-fPzwff25uP7yabNeXRda1E0sZEcokawUFKgE1nFOuZFVRQCw6WrNBHbYtEiB0RKaWmAyZNcy3WpTCV1eZJs9t3Vwo3bejuBvlQOr7hzO9wp8tGZABUYT3ghmmhJ5W3HAklNDSk2kLlE0ifV-z9rNesR26cTDcAQ9jkx2q3r3SzHGBWUyAVZ7gLbuP4DjiHGjWhamloUppphIjDeHIrz7OaeRq9GGZc4woZuDqtPA6oYv1b7eC3tIzdmpcwlpFrFaLUxZ87pOqqtHVOm1OFqT7qqzyX-UcHmUkDQRf8ce5hDU5tvXR-HGuxA8dvetUqKWU_23uVcPJ_xXfrjN8g_KiOcT |
CitedBy_id | crossref_primary_10_3389_fcell_2021_702832 crossref_primary_10_1111_ejn_13219 crossref_primary_10_1007_s12311_014_0628_6 crossref_primary_10_1093_hmg_ddv137 crossref_primary_10_1007_s00429_020_02147_x crossref_primary_10_1038_s41598_017_19116_w crossref_primary_10_1016_j_ydbio_2017_09_036 crossref_primary_10_7554_eLife_20898 crossref_primary_10_1093_genetics_iyad182 crossref_primary_10_1016_j_nbd_2023_106163 crossref_primary_10_1371_journal_pone_0032970 crossref_primary_10_1016_j_neulet_2018_05_013 crossref_primary_10_3389_fcell_2020_613557 crossref_primary_10_3390_toxics3020224 crossref_primary_10_1088_1367_2630_ac03ce crossref_primary_10_7554_eLife_23253 crossref_primary_10_1002_cne_22301 crossref_primary_10_1126_sciadv_abf7262 crossref_primary_10_1080_03079457_2014_889277 crossref_primary_10_1002_hsr2_2233 crossref_primary_10_1016_j_expneurol_2018_05_015 crossref_primary_10_1111_bpa_13162 crossref_primary_10_1126_scisignal_aau5147 crossref_primary_10_1007_s00429_017_1436_9 crossref_primary_10_1242_dev_120287 crossref_primary_10_3389_fnsys_2021_646052 crossref_primary_10_4199_C00096ED1V01Y201310DBR011 crossref_primary_10_3389_fnbeh_2015_00265 crossref_primary_10_1007_s12311_019_01046_0 crossref_primary_10_1016_j_ydbio_2009_02_011 crossref_primary_10_3389_fncel_2018_00484 crossref_primary_10_1002_dvdy_22013 crossref_primary_10_1016_j_ydbio_2022_08_002 crossref_primary_10_1083_jcb_201310136 crossref_primary_10_1016_j_expneurol_2020_113537 crossref_primary_10_1186_s13064_016_0072_z crossref_primary_10_1186_s13578_022_00869_5 crossref_primary_10_1242_dev_185587 crossref_primary_10_1209_0295_5075_97_68008 crossref_primary_10_3390_cells10061453 crossref_primary_10_1002_dneu_22236 crossref_primary_10_1039_C6SM00526H crossref_primary_10_3389_fncir_2018_00083 crossref_primary_10_1103_PhysRevX_8_041053 crossref_primary_10_1242_bio_009886 crossref_primary_10_7554_eLife_45019 crossref_primary_10_1007_s00018_015_2065_1 crossref_primary_10_1111_j_1471_4159_2011_07524_x crossref_primary_10_1073_pnas_0908790107 crossref_primary_10_1523_JNEUROSCI_1282_12_2012 crossref_primary_10_1038_s42003_023_05294_z crossref_primary_10_1016_j_neuroscience_2015_01_026 crossref_primary_10_1016_j_ydbio_2022_10_006 crossref_primary_10_1039_C8SM02231C crossref_primary_10_1016_j_brainres_2013_03_037 crossref_primary_10_1089_ars_2014_6043 crossref_primary_10_1016_j_devcel_2018_02_012 crossref_primary_10_1016_j_ydbio_2012_04_018 crossref_primary_10_1016_j_neuroscience_2017_04_020 crossref_primary_10_1038_srep07827 crossref_primary_10_1242_dev_202184 crossref_primary_10_1371_journal_pone_0064451 crossref_primary_10_4161_cam_25140 crossref_primary_10_1007_s12311_017_0892_3 crossref_primary_10_1016_j_ydbio_2011_07_030 crossref_primary_10_1016_j_neuroscience_2020_06_010 crossref_primary_10_1523_JNEUROSCI_2059_08_2008 crossref_primary_10_1002_ijch_202200071 crossref_primary_10_1007_s12311_011_0251_8 crossref_primary_10_1016_j_ydbio_2010_11_018 crossref_primary_10_1136_jmedgenet_2021_108115 crossref_primary_10_1242_dev_027045 crossref_primary_10_1038_s41583_019_0152_2 crossref_primary_10_1080_19475411_2019_1631899 crossref_primary_10_1523_JNEUROSCI_2158_16_2017 crossref_primary_10_1007_s00429_015_0998_7 crossref_primary_10_1126_science_aam8999 crossref_primary_10_3389_fcell_2020_00231 crossref_primary_10_1038_s41598_019_41940_5 crossref_primary_10_1016_j_pneurobio_2013_08_001 crossref_primary_10_1111_j_1750_3639_2010_00459_x crossref_primary_10_1007_s12311_010_0208_3 crossref_primary_10_1093_hmg_ddt277 crossref_primary_10_1007_s12311_022_01429_w crossref_primary_10_1159_000509068 crossref_primary_10_3389_fphy_2022_837600 crossref_primary_10_1016_j_diff_2022_12_004 crossref_primary_10_1093_hmg_ddp110 crossref_primary_10_1371_journal_pone_0087518 crossref_primary_10_15547_tjs_2023_03_007 crossref_primary_10_1152_jn_00586_2014 crossref_primary_10_1073_pnas_2016830117 crossref_primary_10_1007_s12311_015_0744_y crossref_primary_10_1016_j_freeradbiomed_2017_07_026 crossref_primary_10_1038_s41467_021_25846_3 crossref_primary_10_3389_fncel_2022_903729 crossref_primary_10_1016_j_ydbio_2019_10_002 crossref_primary_10_1038_cdd_2015_39 crossref_primary_10_1016_j_gpb_2016_04_003 crossref_primary_10_1016_j_ydbio_2015_10_007 crossref_primary_10_1007_s12264_018_0228_4 crossref_primary_10_1299_jbse_20_00516 crossref_primary_10_1016_j_expneurol_2013_01_021 crossref_primary_10_1080_1028415X_2024_2312304 crossref_primary_10_1002_dvdy_24526 crossref_primary_10_1007_s12311_015_0724_2 crossref_primary_10_1523_JNEUROSCI_5255_14_2015 crossref_primary_10_1016_j_neuroscience_2015_09_025 crossref_primary_10_1371_journal_pone_0221914 crossref_primary_10_1093_hmg_ddv042 crossref_primary_10_1523_JNEUROSCI_3476_13_2014 crossref_primary_10_1007_s12031_011_9494_6 crossref_primary_10_1523_JNEUROSCI_2674_17_2018 crossref_primary_10_1007_s10646_020_02270_9 crossref_primary_10_1002_ajmg_c_31595 crossref_primary_10_1515_rns_2011_037 crossref_primary_10_1002_cne_25616 crossref_primary_10_1016_j_neuroimage_2015_05_029 crossref_primary_10_1016_j_brainres_2019_146358 crossref_primary_10_1371_journal_pone_0017884 crossref_primary_10_1007_s12311_011_0254_5 crossref_primary_10_1038_cddis_2017_326 crossref_primary_10_1039_C2BM00060A crossref_primary_10_1093_brain_awt340 crossref_primary_10_7554_eLife_39879 crossref_primary_10_1016_j_mad_2013_04_001 crossref_primary_10_1007_s12311_017_0904_3 crossref_primary_10_1084_jem_20182037 crossref_primary_10_3389_fped_2014_00070 crossref_primary_10_1097_NEN_0000000000000171 crossref_primary_10_1038_srep16232 crossref_primary_10_1002_wdev_65 crossref_primary_10_1177_0192623317728134 crossref_primary_10_1016_j_neulet_2018_05_032 crossref_primary_10_1080_10253890_2017_1378637 crossref_primary_10_1159_000446904 crossref_primary_10_1007_s11538_016_0163_3 crossref_primary_10_1016_j_ydbio_2008_11_001 crossref_primary_10_1016_j_neuroscience_2019_03_061 crossref_primary_10_1242_dev_124180 crossref_primary_10_1038_s41598_023_47098_5 crossref_primary_10_1186_s43042_022_00307_8 crossref_primary_10_1038_nn_4020 crossref_primary_10_1016_j_jneuroim_2022_577870 crossref_primary_10_7554_eLife_63668 crossref_primary_10_1016_j_ijdevneu_2017_10_003 crossref_primary_10_1016_j_nbd_2023_106336 crossref_primary_10_1155_2011_315418 crossref_primary_10_7554_eLife_60554 crossref_primary_10_1155_2013_948587 crossref_primary_10_3389_fnmol_2023_1236015 crossref_primary_10_1016_j_ydbio_2011_03_008 crossref_primary_10_7554_eLife_34042 crossref_primary_10_1096_fj_12_205807 crossref_primary_10_1186_s13064_019_0130_4 crossref_primary_10_1016_j_ydbio_2014_08_004 crossref_primary_10_1523_JNEUROSCI_0612_18_2018 crossref_primary_10_1007_s11055_022_01231_5 crossref_primary_10_1186_s13064_017_0096_z crossref_primary_10_1016_j_brainres_2013_08_003 crossref_primary_10_1074_jbc_M112_413500 crossref_primary_10_1002_ar_21082 |
ContentType | Journal Article |
Copyright | COPYRIGHT 2007 BioMed Central Ltd. Copyright © 2007 Sudarov and Joyner; licensee BioMed Central Ltd. 2007 Sudarov and Joyner; licensee BioMed Central Ltd. |
Copyright_xml | – notice: COPYRIGHT 2007 BioMed Central Ltd. – notice: Copyright © 2007 Sudarov and Joyner; licensee BioMed Central Ltd. 2007 Sudarov and Joyner; licensee BioMed Central Ltd. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION ISR 7X8 5PM DOA |
DOI | 10.1186/1749-8104-2-26 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Science in Context MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology |
EISSN | 1749-8104 |
EndPage | 26 |
ExternalDocumentID | oai_doaj_org_article_acb04962c93e4d54ae341c03b08b3e69 oai_biomedcentral_com_1749_8104_2_26 A174987477 10_1186_1749_8104_2_26 18053187 |
Genre | Journal Article |
GeographicLocations | United States |
GeographicLocations_xml | – name: United States |
GroupedDBID | --- -56 -5G -A0 -BR 0R~ 123 29N 2VQ 2WC 4.4 53G 5VS AAFWJ AAJSJ ABDBF ABIVO ACGFO ACGFS ACIHN ACMJI ACPRK ACRMQ ADBBV ADINQ ADRAZ ADUKV AEAQA AENEX AFPKN AHBYD AHMBA AHSBF AHYZX ALIPV ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BFQNJ BMC C24 C6C CGR CS3 CUY CVF DIK DU5 E3Z EBLON EBS ECM EIF EJD EMOBN ESX F5P GROUPED_DOAJ GX1 H13 HYE IAO IHR INH INR IPNFZ IPY ISR ITC KQ8 M~E NPM O5R O5S OK1 P2P P6G PGMZT RBZ RIG RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS WOQ WOW ~8M 3V. 7X7 88E 8FI 8FJ AAYXX ABUWG AFKRA AZQEC BENPR BPHCQ BVXVI CCPQU CITATION DWQXO EBD FYUFA GNUQQ HMCUK LGEZI LOTEE M1P M2M M48 NADUK NXXTH PIMPY PQQKQ PROAC PSQYO PSYQQ UKHRP ABVAZ AFGXO AFNRJ 7X8 5PM |
ID | FETCH-LOGICAL-b679t-8f01082361a18a2f4414c8550aae9f7b26efe9de1a213a976ea218fd2bdbc56b3 |
IEDL.DBID | RPM |
ISSN | 1749-8104 |
IngestDate | Thu Jul 04 21:11:45 EDT 2024 Tue Sep 17 21:10:32 EDT 2024 Wed May 22 07:12:52 EDT 2024 Fri Aug 16 02:15:00 EDT 2024 Fri Feb 23 00:22:01 EST 2024 Fri Feb 02 04:39:52 EST 2024 Sat Sep 28 21:15:08 EDT 2024 Thu Sep 12 19:28:27 EDT 2024 Sat Sep 28 07:55:19 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
License | This is an open access article distributed under the terms of the Creative Commons Attribution License (), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-b679t-8f01082361a18a2f4414c8550aae9f7b26efe9de1a213a976ea218fd2bdbc56b3 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246128/ |
PMID | 18053187 |
PQID | 70107949 |
PQPubID | 23479 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_acb04962c93e4d54ae341c03b08b3e69 pubmedcentral_primary_oai_pubmedcentral_nih_gov_2246128 biomedcentral_primary_oai_biomedcentral_com_1749_8104_2_26 proquest_miscellaneous_70107949 gale_infotracmisc_A174987477 gale_infotracacademiconefile_A174987477 gale_incontextgauss_ISR_A174987477 crossref_primary_10_1186_1749_8104_2_26 pubmed_primary_18053187 |
PublicationCentury | 2000 |
PublicationDate | 2007-12-03 |
PublicationDateYYYYMMDD | 2007-12-03 |
PublicationDate_xml | – month: 12 year: 2007 text: 2007-12-03 day: 03 |
PublicationDecade | 2000 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Neural development |
PublicationTitleAlternate | Neural Dev |
PublicationYear | 2007 |
Publisher | BioMed Central Ltd BioMed Central BMC |
Publisher_xml | – name: BioMed Central Ltd – name: BioMed Central – name: BMC |
References | 9733080 - J Comp Neurol. 1998 Sep 28;399(3):306-20 14473282 - Exp Neurol. 1961 Oct;4:277-96 10226030 - Curr Biol. 1999 Apr 22;9(8):445-8 2892757 - Genes Dev. 1987 Mar;1(1):29-38 1726564 - Development. 1991 Nov;113(3):841-50 8602221 - Nature. 1996 Feb 22;379(6567):736-9 4844095 - Brain Res. 1974 Aug 9;76(1):33-40 15024754 - J Comp Neurol. 2004 Apr 19;472(1):87-99 11160432 - J Neurosci. 2001 Jan 15;21(2):527-40 12012426 - J Comp Neurol. 2002 Jun 24;448(2):138-49 17314475 - Brain Behav Evol. 2007;69(4):280-300 2199841 - Neuroscience. 1990;35(2):375-475 2215915 - Neuroscience. 1990;36(1):121-44 2319628 - J Neurosci Res. 1990 Feb;25(2):194-203 17392791 - Nature. 2007 Apr 12;446(7137):797-800 17506688 - Annu Rev Cell Dev Biol. 2007;23:549-77 17311471 - PLoS Biol. 2007 Mar;5(3):e53 17507571 - J Neurosci. 2007 May 16;27(20):5495-505 15102908 - J Neurosci. 2004 Apr 21;24(16):3926-32 16002452 - J Physiol. 2005 Sep 15;567(Pt 3):829-50 8161459 - Neuron. 1994 Apr;12(4):895-908 17872929 - Brain. 2007 Oct;130(Pt 10):2646-60 1672471 - Science. 1991 Mar 8;251(4998):1239-43 15157725 - Prog Neurobiol. 2004 Apr;72(5):295-339 15836427 - PLoS Biol. 2005 May;3(5):e159 5788129 - J Comp Neurol. 1969 Jul;136(3):269-93 7381062 - J Comp Neurol. 1980 Mar 15;190(2):357-62 16871622 - Dev Dyn. 2006 Sep;235(9):2376-85 4165738 - J Comp Neurol. 1966 Oct;128(2):245-54 8469990 - Science. 1993 Apr 16;260(5106):367-9 16571625 - Development. 2006 May;133(9):1811-21 15254551 - Nature. 2004 Aug 5;430(7000):689-93 15496441 - Development. 2004 Nov;131(22):5581-90 15737927 - Dev Cell. 2005 Mar;8(3):305-20 16202705 - Neuron. 2005 Oct 6;48(1):17-24 17537797 - Development. 2007 Jun;134(12):2325-35 2268185 - Arch Ital Biol. 1990 Jul;128(2-4):87-109 10700185 - Nat Genet. 2000 Mar;24(3):287-90 9002514 - Nature. 1997 Jan 23;385(6614):313-8 2209800 - Experientia. 1990 Sep 15;46(9):907-16 16205717 - Nat Neurosci. 2005 Nov;8(11):1516-24 6799550 - J Comp Neurol. 1981 Dec 20;203(4):751-69 15800897 - Glia. 2005 Aug 15;51(3):229-34 4128371 - J Comp Neurol. 1973 Nov 15;152(2):103-32 6479439 - Dev Biol. 1984 Oct;105(2):257-72 7909289 - Development. 1994 Mar;120(3):695-706 11433373 - Nat Rev Neurosci. 2001 Jul;2(7):484-91 9315908 - J Neurosci. 1997 Oct 15;17(20):7881-9 9204478 - Mol Cell Neurosci. 1997 Jan;9(1):26-41 10409504 - Development. 1999 Aug;126(16):3585-96 16604528 - Genesis. 2006 Apr;44(4):202-18 15377747 - J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78 7600988 - Development. 1995 Jun;121(6):1719-30 5478302 - Brain Res. 1970 Oct 28;23(3):343-52 9043067 - Development. 1997 Feb;124(4):861-70 1786652 - Brain Res Dev Brain Res. 1991 Dec 17;64(1-2):95-114 15183722 - Dev Biol. 2004 Jun 15;270(2):393-410 11299042 - BMC Dev Biol. 2001;1:4 |
References_xml | |
SSID | ssj0050268 |
Score | 2.2871819 |
Snippet | The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a broad... BACKGROUNDThe cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a... BACKGROUND: The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely serve as a... Abstract Background The cerebellum has a striking morphology consisting of folia separated by fissures of different lengths. Since folia in mammals likely... |
SourceID | doaj pubmedcentral biomedcentral proquest gale crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 26 |
SubjectTerms | Animals Body Patterning - physiology Cell Communication - physiology Cell Differentiation - physiology Cell Movement - physiology Cell Proliferation Cerebellar Cortex - cytology Cerebellar Cortex - embryology Cerebellar Cortex - metabolism Cerebellum Cerebellum - cytology Cerebellum - embryology Cerebellum - metabolism Female Gene Expression Regulation, Developmental - physiology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Male Mice Mitotic Index Models, Neurological Morphogenesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neuroglia - cytology Neuroglia - metabolism Neurological research Neurons - cytology Neurons - metabolism Purkinje Cells - cytology Purkinje Cells - metabolism Stem Cells - cytology Stem Cells - metabolism Structure |
SummonAdditionalLinks | – databaseName: BioMedCentral Open Access (Free Resource) dbid: RBZ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagSIgLgpbHQgELIThFrO3EdnrbVlQFCQ5ApYqL5VfalbpJtdk99N8z42Rp3T1yW8XjrON5eGY8_kzIh8rW2ikXCs81BChOgR0MoHiqrERgJUOnHastfsiT0_LbWXV2k--4s4PPtPwMLjMmqqZlwQsu75MHHCHOMS4__LOxuRVEEno4-jjQjvCM2_3vnGu_zJajhNq_bZtvLU554eStlej4CXk8upB0NvD8KbkX212yN2shfF5c0480FXWmbPkuefh93DvfI_4oLiNuM6wXdNHB9HbnaOfm_QEFJ5A23eXAJXqVIDdbOu9pt0z3aSGcRKDumqbywwKT_Vi9SkFiLlIBH8WhgiP5jJwef_l9dFKMVywUTqp6VegG4jG885xZpi1vwDkqPWKcWRvrRjkuYxPrEJnlTFhwXSL80E3gLjhfSSeek522a-NLQplQzIUpNFhZSum0FVXjgg0KPDSl44QcZDNvrgY4DYMA13kL6JpBthlkm-GGywn5tGHTv34pfNFyi_IQuZi9PT0AmTKjNhrrHURGkvtaxDJUpY2wmPupcFPtRJT1hLxHGTAIkNFiBc65Xfe9-frrp5nh32kIwhSMaSRqOhi2t-OBBpgOxNTKKPczStBgnzW_24iawSYse2tjt-6NAu6AwYTxvBgE7-bjNVpPDX1VJpLZd-ct7fwiwYcnCEGuX_0PP16TRynJjXU9Yp_srJbr-Aa8s5V7mxTzL3iRN-g priority: 500 providerName: BioMedCentral – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3BbtQwELVQD4gLgrbAQgGrQnCKurYT2-ltqajaSnAAKvVm2bHTrtRNqs3uoX_PjJ0ta_XAhVsUO4k9Mx7POM_PhHyqbK2dcr5ouIYExSnwgx4Gnior4VnJMGhHtMUPeXZZXlxVV1tHfSEmLNEDJ8Ed2cZBECt5U4tQ-qq0AfxuMxVuqp0IMm3dY9UmmUo-uILMQqetkLjINS1Hukam5dHDvYIXSKmQ7XO_zaanyOL_2FdvTVY5kHJrZjp9QZ6PISWdpa68JE9Ct0v2Zh2k04t7-plGkGdcPd8lT7-P_9L3SHMSlgF_O6wXdNGDuPtr9Hvz4ZhCUEjb_jZpjd5FCs6OzgfaL-P5Wkgv4am7pxGOWODiP6JZKVjQTQT0UWwqBJb75PL02--Ts2I8cqFwUtWrQreQn-EZ6MwybXkLwVLZIOeZtaFuleMytKH2gVnOhIVQJsCFbj133jWVdOIV2en6LrwhlAnFnJ9CgZWllE5bUbXOW68gYlM6TMhxJnlzl-g1DBJe5yUw9gyqzaDaDDdcTsiXjZoenovpjJaPan5FLWZvjzfAyMxoZOZfRjYhh2gDBgkzOkTkXNv1MJjzXz_NDD-nISlT0KaxUttDsxs7bnAAcSDHVlbzIKsJI7rJij9uTM1gEcLgutCvB6NAO-BAoT2vk-H97bxGb6rhWZWZZNbvvKSb30Q68UgpyPXb_yGod-RZXPxGvI84IDur5Tq8h6ht5T7EAfoHsuFAAw priority: 102 providerName: Directory of Open Access Journals |
Title | Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers |
URI | https://www.ncbi.nlm.nih.gov/pubmed/18053187 https://search.proquest.com/docview/70107949 http://dx.doi.org/10.1186/1749-8104-2-26 https://pubmed.ncbi.nlm.nih.gov/PMC2246128 https://doaj.org/article/acb04962c93e4d54ae341c03b08b3e69 |
Volume | 2 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Nb9MwFLe2ISEuCDY-CqNYCMEpa2MntrNbVzGNSkNoY9LExbJjp6vUJFU_Dvvvec9NYdZuXKqqdhrH78Pvvfz8MyGfc1MoK61LSqYgQbES_KADw5NZzl2apRi0I9rih7i4ySa3-e0eyXd7YQJov7Szk2ZenzSzu4CtXNTlYIcTG_y8HAcSNKYG-2Rfcr5L0bfuN4ekQnXsjKkSA4i4sc41zBKWsHBgkUK9QwhdtMN9Hi1Mgb__sZd-sEzFEMoHa9L5C_K8CybpaDvol2TPN4fkaNRAIl3f0y80wDtD3fyQPL3s3qIfkXLslx5fOGxqWrcw0e0UPd5sdUohHKRVO9_Kiy4C-WZDZyvaLsPJWkgs4ai9pwGImGDZH3GsFHTnLkD5KA4VQspX5Ob826_xRdIdtpBYIYt1oirIzPD089SkyrAKwqSsRLYzY3xRScuEr3zhfGpYyg0EMR6-qMox62yZC8tfk4OmbfxbQlMuU-uG0GBEJoRVhueVdcZJiNWk8j1yGs28XmyJNTRSXcctYHUaJahRgpppJnrk605Mf68LiYwSj3qeoRSjfw8_tMup7tRJm9JCjiRYWXCfuTwzHpb1csjtUFnuRdEjn1AHNFJlNIjFmZrNaqW_X1_pEd5OQTomYUxdp6qFYZem29oA04HsWlHP46gn2HIZNX_cqZrGJgTANb7drLQE6YDrhPG82Srev4fv9LlHZKSS0XPHLWBXgUi8s6N3_33le_Is1LoR3sOPycF6ufEfIEhb2z55MhpNrif9UOSAz6uz3_1gqH8AIAZCHQ |
link.rule.ids | 108,230,315,733,786,790,870,891,2115,24965,27957,27958,53827,53829,76169,76170 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLbGkIALPzYGhcEshOCUtnES29mtVEwbrBOCDe1m2Y7TVbRJ1R-H8dfznpPCzE5wq_qc1o4_P79nf_5MyNtM59IIU0SWSUhQjAA_WMDAE2mWFHEaY9CObIszfnyRfrrMLrdItjkL40n71ky61XTWrSZXnls5n9nehifW-zIaehE0Jnt3yF0Yr0xskvTGAWeQVshWnzGWvAcxN6509dOIRcxfWSQReUiiC864T4OpySv43_bTNyaqkER5Y1Y6ekS-b9rTkFF-dNcr07U__5J6_OcGPyYP2ziVDhrzE7Llqh2yO6ggR59d03fUM0f9kvwOuTdqN-h3iR26hcO9jPWMzmrow3qMznSyPKQQadKynjZQoHOv61nRyZLWC39pF2pWFNRcU89xjHBHASmyFGB55VmCFN8BRKtPycXRx_PhcdTe4xAZLvJVJEtI-vBi9VjHUrMSIrDUopCa1i4vhWHclS4vXKxZnGiIjxx8kGXBTGFsxk2yR7arunLPCY0TEZuiDwbNU86N1ElWmkIXAsJAIV2HHAZdquaNZodCFe3QAgNaITQUQkMxxXiHvN_0_-_nfI4k-a2SHxAewa_7L-rFWLUdp7Q1kH5xZvPEpUWWagcRg-0npi9N4njeIW8QXApVOCqk-Yz1erlUJ9--qgH-nYRMT0Cd2kJlDdW2uj01Aa8DhbuCkvtBSXATNjAfbDCs0ITcusrV66US0DvglaE-zxpE_2l8O1A6RARYD9odWgDBXqO8ReyL_37ygNw_Ph-dqtOTs88vyQO_pI4somSfbK8Wa_cKYsGVee1H_i_WGmB- |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLZgSBMvXDYuhcEshOApbeMkjrO3Uqg2YNMETJp4sXxLV9EmVS8P49dzjpNCzd72VsUnqR1_Pj7H_vKZkLeZKoTOtY0ME5Cg6Bz8oIWBl6dZYuM0xqAd2RZn_Pgi_XyZXW4d9eVJ-0ZPutV01q0mV55bOZ-Z3oYn1js_HXoRNCZ6c1v27pJ7MGZZsUnUGyecQWohWo3GWPAexN242tVPIxYxf2yRQPQhkS74zn0aTE9exf-mr96arEIi5dbMNHpIfm7a1BBSfnXXK901v_-Te7xVox-RB228SgeNyWNyx1V7ZH9QQa4-u6bvqGeQ-qX5PbJ72m7U7xMzdAuHexrrGZ3V0Jf1GJ3qZHlEIeKkZT1tIEHnXt-zopMlrRf-8C7UrrBUX1PPdYxwZwGpshTgeeXZghTfA0StT8jF6NOP4XHUnucQaZ4Xq0iUkPzhAeuxioViJURiqUFBNaVcUeaacVe6wrpYsThRECc5-CFKy7TVJuM6eUp2qrpyzwmNkzzWtg8Fiqeca6GSrNRW2RzCwVy4DjkKulXOG-0OiWraYQkMbInwkAgPySTjHfJ-g4G_9_lcSfAblh8QIsHT_YV6MZZt50llNKRhnJkicanNUuUgcjD9RPeFThwvOuQNAkyiGkeFdJ-xWi-X8uT7NznAvxOQ8eVQp9aorKHaRrVfT8DrQAGvwPIgsAR3YYLiww2OJRYhx65y9Xopc-gd8M5Qn2cNqv81vh0sHZIHeA_aHZYAir1WeYvaF7e-85Dsnn8cya8nZ19ekvt-ZR3JRMkB2Vkt1u4VhIQr_doP_j-lImL- |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cerebellum+morphogenesis%3A+the+foliation+pattern+is+orchestrated+by+multi-cellular+anchoring+centers&rft.jtitle=Neural+development&rft.au=Sudarov%2C+Anamaria&rft.au=Joyner%2C+Alexandra+L&rft.date=2007-12-03&rft.pub=BioMed+Central&rft.eissn=1749-8104&rft.volume=2&rft.spage=26&rft.epage=26&rft_id=info:doi/10.1186%2F1749-8104-2-26&rft_id=info%3Apmid%2F18053187&rft.externalDBID=PMC2246128 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1749-8104&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1749-8104&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1749-8104&client=summon |