Small noncoding RNA modulates japanese encephalitis virus replication and translation in trans

• Published in: Virology journal Vol. 8; no. 1; p. 492
• Main Authors: Fan, Yi-Hsin, Nadar, Muthukumar, Chen, Chiu-Chin, Weng, Chia-Chen, Lin, Yun-Tong, Chang, Ruey-Yi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.11.2011; BioMed Central; BMC
• Subjects: 3' untranslated regions; Animals; Blotting, Northern; Cell Line; Cricetinae; Cytoplasm; Encephalitis Virus, Japanese - genetics; Encephalitis Virus, Japanese - physiology; Gene Expression Regulation, Viral; genes; Genetic aspects; Genomes; Japanese encephalitis; Japanese encephalitis virus; Life sciences; luciferase; Models, Biological; Mortality; non-coding RNA; Northern blotting; Open reading frames; Polymerase chain reaction; Protein Biosynthesis; Proteins; Real-Time Polymerase Chain Reaction; Risk factors; RNA, Small Untranslated - metabolism; RNA, Viral - metabolism; Statistical analysis; Studies; transfection; Virus Replication; Viruses; Taiwan

Sequence and structural elements in the 3'-untranslated region (UTR) of Japanese encephalitis virus (JEV) are known to regulate translation and replication. We previously reported an abundant accumulation of small subgenomic flaviviral RNA (sfRNA) which is collinear with the highly conserved re...