Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling

• Published in: Molecular cancer Vol. 9; no. 1; p. 283
• Main Authors: Wu, Meng-Ju, Jan, Chia-Ing, Tsay, Yeou-Guang, Yu, Yau-Hua, Huang, Chih-Yang, Lin, Shu-Chun, Liu, Chung-Ji, Chen, Yu-Syuan, Lo, Jeng-Fan, Yu, Cheng-Chia
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.10.2010; BioMed Central; BMC
• Subjects: Animals; Biology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell Line; Cell Movement - genetics; Cell Movement - physiology; Cellular signal transduction; Flow Cytometry; Gene Expression Profiling; Genetic aspects; Head & neck cancer; Head and neck cancer; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Health aspects; Heat-Shock Proteins - genetics; Heat-Shock Proteins - metabolism; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular chaperones; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Oligonucleotide Array Sequence Analysis; Physiological aspects; Protein folding; Risk factors; RNA Interference; Rodents; Science; Signal Transduction; Stem cells; Survival analysis; Taiwan

Head and neck squamous cell carcinoma (HNSCC) is a highly lethal cancer that contains cellular and functional heterogeneity. Previously, we enriched a subpopulation of highly tumorigenic head and neck cancer initiating cells (HN-CICs) from HNSCC. However, the molecular mechanisms by which to govern...