Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

• Published in: Diagnostic pathology Vol. 7; no. 1; p. 87
• Main Authors: Guzmán, Leda, Depix, María Soledad, Salinas, Ana María, Roldán, Rosa, Aguayo, Francisco, Silva, Alejandra, Vinet, Raul
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.07.2012; BioMed Central; BMC
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Cancer; Cell cycle; Cigarettes; Comparative analysis; COPD; Cyclin-dependent kinases; Deoxyribonucleic acid; Diagnosis; Disease; DNA; DNA - analysis; DNA methylation; DNA Methylation - genetics; DNA repair; Early Detection of Cancer - methods; Epigenetic inheritance; Epigenetics; Gene expression; Genes; Genes, Tumor Suppressor; Genetic aspects; Genetic research; Hospitals; Humans; Lung cancer; Lung diseases; Lung diseases, Obstructive; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Methylation; Middle Aged; Mortality; Physiological aspects; Promoter Regions, Genetic - genetics; Promoters (Genetics); Proteins; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - genetics; Signal transduction; Smokers; Smoking; Smoking - adverse effects; Sputum; Sputum - chemistry; Studies; Tobacco; Tumors; Young Adult; Chile

Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In this study, we hypothesize that tobacco smokers are susceptible fo...