278 Effect of topical imiquimod treatment in the expression of the HPV E7 and human CD28 and CTLA-4 immune molecules in the high-grade cervical lesion

• Published in: International journal of gynecological cancer Vol. 34; no. Suppl 1; pp. A493 - A494
• Main Authors: Cokan, Andrej, Henrique Da Silva, Neila Caroline, De Arruda, Débora Rayane, Zeferino Araujo, Nathália Lorena, Da Silva, Rodrigo Soares, Alves Peixoto, Christina, De Oliveira, Sheilla Andrade, Kavalar, Rajko, Pakiž, Maja, But, Igor, Lucena Silva, Norma
• Format: Journal Article
• Language: English
• Published: Oxford BMJ Publishing Group Ltd 10.03.2024; BMJ Publishing Group LTD
• Subjects: Human papillomavirus; Lymphocytes; Poster and E-Posters; Success

Introduction/BackgroundPersistent high-risk Human Papillomavirus (HPV) infection and the prolonged existence of cervical lesions are concomitant with heightened E7 oncoprotein expression, disrupting both innate and adaptive immunity. The delicate balance between stimulatory CD28-expressing T cells a...