Reduced body weight is a common effect of gene knockout in mice

• Published in: BMC genetics Vol. 9; no. 1; p. 4
• Main Authors: Reed, Danielle R, Lawler, Maureen P, Tordoff, Michael G
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.01.2008; BioMed Central; BMC
• Subjects: Alleles; Animals; Body weight; Correspondence; Databases, Genetic; Genetically modified mice; Genome; Mice; Mice, Congenic; Mice, Knockout - physiology; Phenotype; Quantitative Trait Loci; Species Specificity; Weight Loss - genetics

During a search for obesity candidate genes in a small region of the mouse genome, we noticed that many genes when knocked out influence body weight. To determine whether this was a general feature of gene knockout or a chance occurrence, we surveyed the Jackson Laboratory Mouse Genome Database for...