Cognitive deficits following anti-NMDA receptor encephalitis

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 83; no. 2; pp. 195 - 198
• Main Authors: Finke, Carsten, Kopp, Ute A, Prüss, Harald, Dalmau, Josep, Wandinger, Klaus-Peter, Ploner, Christoph J
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.02.2012; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adult; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - etiology; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - psychology; Autoantibodies - analysis; Autoantibodies - blood; Autoantibodies - cerebrospinal fluid; Autoimmune Diseases - complications; Autoimmune Diseases - psychology; Biological and medical sciences; Brain - pathology; Brain damage; Cerebrospinal fluid; clinical neurology; cognition; Cognition Disorders - etiology; Cognition Disorders - psychology; cognitive neuropsychology; Color Perception - physiology; dementia; Encephalitis; Executive function; eye movements; Female; Hippocampus - physiopathology; Humans; Immunoglobulins; immunology; Immunotherapy; Injuries of the nervous system and the skull. Diseases due to physical agents; Intensive care; Learning Disabilities - etiology; Learning Disabilities - psychology; limbic system; Magnetic Resonance Imaging; Male; Medical sciences; Memory; Memory Disorders - etiology; Memory Disorders - psychology; neuroanatomy; Neurology; neurooncology; Neuropsychological Tests; Neuropsychology; NMDA; Ovaries; paraneoplastic syndrome; Patients; Psychomotor Performance - physiology; Receptors, N-Methyl-D-Aspartate - immunology; Traumas. Diseases due to physical agents; Whipple's disease; Young Adult; Encephalitis; Nervous system diseases; Cognitive disorder; Central nervous system disease; Glutamate receptor; NMDA receptor; Cerebral disorder

BackgroundAnti-NMDA receptor (NMDAR) encephalitis is a recently characterised autoimmune disorder mainly affecting young women. Although the clinical features of the acute disease are well characterised, cognitive long-term outcome has not been examined in detail.MethodsThe authors investigated cogn...