Differential effects of tactile high- and low-frequency stimulation on tactile discrimination in human subjects

• Published in: BMC neuroscience Vol. 9; no. 1; p. 9
• Main Authors: Ragert, Patrick, Kalisch, Tobias, Bliem, Barbara, Franzkowiak, Stephanie, Dinse, Hubert R
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.01.2008; BioMed Central; BMC
• Subjects: Adult; Afferent Pathways - physiology; Depression, Mental; Discrimination Learning - physiology; Fingers - innervation; Fingers - physiology; Humans; Long-term potentiation; Long-Term Potentiation - physiology; Mechanoreceptors - physiology; Neural transmission; Neuronal Plasticity - physiology; Neuropsychological Tests; Physical Stimulation - methods; Physiological aspects; Psychophysics - methods; Sensory Receptor Cells - physiology; Sensory Thresholds - physiology; Somatosensory Cortex - physiology; Time Factors; Touch - physiology; Vibration; Germany

Long-term potentiation (LTP) and long-term depression (LTD) play important roles in mediating activity-dependent changes in synaptic transmission and are believed to be crucial mechanisms underlying learning and cortical plasticity. In human subjects, however, the lack of adequate input stimuli for...