HIV-1 subtype C superinfected individuals mount low autologous neutralizing antibody responses prior to intrasubtype superinfection

• Published in: Retrovirology Vol. 9; no. 1; p. 76
• Main Authors: Basu, Debby, Kraft, Colleen S, Murphy, Megan K, Campbell, Patricia J, Yu, Tianwei, Hraber, Peter T, Irene, Carmela, Pinter, Abraham, Chomba, Elwyn, Mulenga, Joseph, Kilembe, William, Allen, Susan A, Derdeyn, Cynthia A, Hunter, Eric
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2012; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; AIDS; Antibodies; Antibodies, Neutralizing - blood; BASIC BIOLOGICAL SCIENCES; Case-Control Studies; Cell Line; Comparative analysis; Development and progression; Disease transmission; Genetic aspects; Genomes; Genomics; Health aspects; HIV; HIV (Viruses); HIV Antibodies - blood; HIV Envelope Protein gp120 - genetics; HIV Envelope Protein gp120 - immunology; HIV infection; HIV Infections - blood; HIV Infections - immunology; HIV Infections - virology; HIV-1 - genetics; HIV-1 - immunology; HIV-1 dual infection; HIV-1 superinfection; HIV-1 transmission; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immune response; Immunity, Humoral; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin G; Immunoglobulin G - blood; Infection; Infections; Medical research; Molecular Sequence Data; Neutralizing antibodies; Peptide Fragments - immunology; Phylogeography; Physiological aspects; Plasma; Risk factors; Sequence Analysis, DNA; Studies; Subtype C; Superinfection - virology; Vaccines; Viral antibodies; Virology; United States; Atlanta Georgia; Georgia

The potential role of antibodies in protection against intra-subtype HIV-1 superinfection remains to be understood. We compared the early neutralizing antibody (NAb) responses in three individuals, who were superinfected within one year of primary infection, to ten matched non-superinfected controls...