D14 Plasma levels of 24S-hydroxycholesterol are reduced in Huntington disease subjects: preliminary results of a 2-year longitudinal study

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 93; no. Suppl 1; p. A25
• Main Authors: Fichera, Mario, Nanetti, Lorenzo, Favagrossa, Monica, Castaldo, Anna, Nigri, Anna, Mongelli, Alessia, Marchini, Gloria, Gellera, Cinzia, Grisoli, Marina, Birolini, Giulia, Valenza, Marta, Bagnati, Renzo, Passoni, Alice, Colombo, Laura, Cattaneo, Elena, Salmona, Mario, Mariotti, Caterina
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.09.2022; BMJ Publishing Group LTD
• Subjects: 24-OHC; Basal ganglia MRI volumes; Biomarker; Cholesterol; D: Wet biomarkers; Huntingtons disease; Longitudinal studies; Longitudinal study; Plasma

ObjectivesBrain cholesterol is produced in situ and its turn-over is ensured by the conversion into 24S-hydroxycholesterol (24-OHC) which can cross the blood-brain barrier. Brain biosynthesis was shown to be reduced in murine models of Huntington’s disease (HD) and 24-OHC plasma concentrations were...