Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 77; no. 2; pp. 149 - 153
• Main Authors: van den Heuvel, D M J, ten Dam, V H, de Craen, A J M, Admiraal-Behloul, F, Olofsen, H, Bollen, E L E M, Jolles, J, Murray, H M, Blauw, G J, Westendorp, R G J, van Buchem, M A
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.02.2006; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Aged; Aged, 80 and over; aging; Biological and medical sciences; Cerebral Infarction - diagnosis; Cerebral Infarction - drug therapy; Cerebral Infarction - pathology; Cerebral Ventricles - pathology; Cerebrospinal fluid; Clinical significance; cognition; Cognition Disorders - diagnosis; Cognition Disorders - psychology; Cognitive ability; deep white matter hyperintensities; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dementia, Vascular - diagnosis; Dementia, Vascular - drug therapy; Dementia, Vascular - pathology; Disease Progression; Double-Blind Method; DWMH; DWMH, deep white matter hyperintensities; Executive function; Female; FLAIR; FLAIR, fluid attenuated inversion recovery; fluid attenuated inversion recovery; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Image Processing, Computer-Assisted; LDCT; LDCT, Letter Digit Coding Test; Letter Digit Coding Test; Longitudinal Studies; Magnetic Resonance Imaging; Male; Medical sciences; MRI; MRI, magnetic resonance imaging; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Neuropsychological Tests; Older people; periventricular white matter hyperintensities; Pravastatin - adverse effects; Pravastatin - therapeutic use; Prospective Studies; PROspective Study of Pravastatin in the Elderly at Risk; PROSPER; PROSPER, PROspective Study of Pravastatin in the Elderly at Risk; PVWMH; PVWMH, periventricular white matter hyperintensities; Reaction Time - physiology; Statistics as Topic; white matter hyperintensities; WMH; WMH, white matter hyperintensities; Human; Speed; Nervous system diseases; Elderly; White matter; Hyperintensity

Objective: To investigate the influence of deep white matter hyperintensities (DWMH) and periventricular white matter hyperintensities (PVWMH) on progression of cognitive decline in non-demented elderly people. Methods: All data come from the nested MRI sub-study of the PROspective Study of Pravasta...