Role of extrathyroidal TSHR expression in adipocyte differentiation and its association with obesity

• Published in: Lipids in health and disease Vol. 11; no. 1; p. 17
• Main Authors: Lu, Sumei, Guan, Qingbo, Liu, Yuantao, Wang, Haibo, Xu, Wei, Li, Xia, Fu, Yuchang, Gao, Ling, Zhao, Jiajun, Wang, Xiangdong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.01.2012; BioMed Central; BMC
• Subjects: 3T3-L1 Cells; Adipocytes - metabolism; Adipocytes - physiology; Adipogenesis; Animals; Body Mass Index; Cell differentiation; Diet, High-Fat - adverse effects; Fat cells; Female; Gene expression; Gene Expression Regulation; Gene Knockdown Techniques; Genetic aspects; Humans; Intra-Abdominal Fat - metabolism; Intra-Abdominal Fat - pathology; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Obesity; Obesity - etiology; Obesity - metabolism; Obesity - pathology; Physiological aspects; Receptors, Thyrotropin - genetics; Receptors, Thyrotropin - metabolism; Risk factors; Rodents; Software; Statistical analysis; Stem cells; Subcutaneous Fat - metabolism; Subcutaneous Fat - pathology; Transcription, Genetic; TSHR; United States; China

Obesity is known to be associated with higher risks of cardiovascular disease, metabolic syndrome, and diabetes mellitus. Thyroid-stimulating hormone (TSHR) is the receptor for thyroid-stimulating hormone (TSH, or thyrotropin), the key regulator of thyroid functions. The expression of TSHR, once con...