Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk

• Published in: Gut Vol. 60; no. 9; pp. 1189 - 1195
• Main Authors: de Sablet, Thibaut, Piazuelo, M Blanca, Shaffer, Carrie L, Schneider, Barbara G, Asim, Mohammad, Chaturvedi, Rupesh, Bravo, Luis E, Sicinschi, Liviu A, Delgado, Alberto G, Mera, Robertino M, Israel, Dawn A, Romero-Gallo, Judith, Peek, Richard M, Cover, Timothy L, Correa, Pelayo, Wilson, Keith T
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.09.2011; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adult; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Bacterial Typing Techniques; Biological and medical sciences; Biopsy; Cell Transformation, Neoplastic - genetics; Chronic illnesses; Coasts; DNA Damage; Endoscopy; gastric atrophy; Gastric cancer; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; gastritis; Gastroenterology. Liver. Pancreas. Abdomen; Helicobacter Infections - complications; Helicobacter Infections - microbiology; Helicobacter Infections - pathology; Helicobacter pylori; Helicobacter pylori - classification; Helicobacter pylori - genetics; Helicobacter pylori - pathogenicity; Helicobacter pylori infection; Histopathology; Human bacterial diseases; Human subjects; Humans; Immunohistochemistry; infection; Infections; Infectious diseases; intestinal metaplasia; Lesions; Male; Males; Medical sciences; Middle Aged; Mountains; multi-locus sequence typing; Multilocus sequence typing; Phylogeny; Phylogeography; Precancerous Conditions - genetics; Precancerous Conditions - microbiology; Precancerous Conditions - pathology; Stomach Neoplasms - genetics; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumorigenesis; Tumors; Ulcers; Colombia; Andes Mountains; United States > US; Nashville Tennessee; Spirillales; Helicobacter pylori; Risk factor; Gastroenterology; Spirillaceae; Bacteria; Digestive diseases; Malignant tumor; Stomach cancer; Cancer; Gastric disease

Background and aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is near...