Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk
Background and aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is near...
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| Published in | Gut Vol. 60; no. 9; pp. 1189 - 1195 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.09.2011
BMJ Publishing Group BMJ Publishing Group LTD |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background and aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions.MethodsMulti-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry.ResultsWe show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters.ConclusionThe phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. |
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| AbstractList | Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions.BACKGROUND AND AIMSHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions.Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry.METHODSMulti-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry.We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters.RESULTSWe show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters.The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection.CONCLUSIONThe phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. Background and aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions.MethodsMulti-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry.ResultsWe show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters.ConclusionThe phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. Background and aims Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. Methods Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. Results We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. Conclusion The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. BACKGROUND AND AIMS: Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high ( similar to 90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. METHODS: Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Narino, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. RESULTS: We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. CONCLUSION: The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection. |
| Author | Israel, Dawn A Peek, Richard M Shaffer, Carrie L Wilson, Keith T Schneider, Barbara G Cover, Timothy L Bravo, Luis E Chaturvedi, Rupesh Mera, Robertino M Romero-Gallo, Judith Delgado, Alberto G Correa, Pelayo Sicinschi, Liviu A Asim, Mohammad Piazuelo, M Blanca de Sablet, Thibaut |
| AuthorAffiliation | 5 Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA 4 Veterans Affairs Tennessee Valley Healthcare System, Nashville, USA 1 Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA 3 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, USA 2 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, USA 6 Department of Pathology, Universidad del Valle School of Medicine, Cali, Colombia |
| AuthorAffiliation_xml | – name: 5 Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA – name: 1 Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – name: 3 Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, USA – name: 6 Department of Pathology, Universidad del Valle School of Medicine, Cali, Colombia – name: 4 Veterans Affairs Tennessee Valley Healthcare System, Nashville, USA – name: 2 Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, USA |
| Author_xml | – sequence: 1 givenname: Thibaut surname: de Sablet fullname: de Sablet, Thibaut organization: Veterans Affairs Tennessee Valley Healthcare System, Nashville, USA – sequence: 2 givenname: M Blanca surname: Piazuelo fullname: Piazuelo, M Blanca organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 3 givenname: Carrie L surname: Shaffer fullname: Shaffer, Carrie L organization: Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, USA – sequence: 4 givenname: Barbara G surname: Schneider fullname: Schneider, Barbara G organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 5 givenname: Mohammad surname: Asim fullname: Asim, Mohammad organization: Veterans Affairs Tennessee Valley Healthcare System, Nashville, USA – sequence: 6 givenname: Rupesh surname: Chaturvedi fullname: Chaturvedi, Rupesh organization: Veterans Affairs Tennessee Valley Healthcare System, Nashville, USA – sequence: 7 givenname: Luis E surname: Bravo fullname: Bravo, Luis E organization: Department of Pathology, Universidad del Valle School of Medicine, Cali, Colombia – sequence: 8 givenname: Liviu A surname: Sicinschi fullname: Sicinschi, Liviu A organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 9 givenname: Alberto G surname: Delgado fullname: Delgado, Alberto G organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 10 givenname: Robertino M surname: Mera fullname: Mera, Robertino M organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 11 givenname: Dawn A surname: Israel fullname: Israel, Dawn A organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 12 givenname: Judith surname: Romero-Gallo fullname: Romero-Gallo, Judith organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 13 givenname: Richard M surname: Peek fullname: Peek, Richard M organization: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, USA – sequence: 14 givenname: Timothy L surname: Cover fullname: Cover, Timothy L organization: Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, USA – sequence: 15 givenname: Pelayo surname: Correa fullname: Correa, Pelayo organization: Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA – sequence: 16 givenname: Keith T surname: Wilson fullname: Wilson, Keith T email: keith.wilson@vanderbilt.edu organization: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, USA |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24420092$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21357593$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. 2015 INIST-CNRS 2011 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. |
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| DOI | 10.1136/gut.2010.234468 |
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| Issue | 9 |
| Keywords | Spirillales Helicobacter pylori Risk factor Gastroenterology Spirillaceae Bacteria Digestive diseases Malignant tumor Stomach cancer Cancer Gastric disease |
| Language | English |
| License | CC BY 4.0 |
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| Notes | ark:/67375/NVC-WMCXP5C6-J href:gutjnl-60-1189.pdf PMID:21357593 ArticleID:gutjnl234468 istex:DF9F4FBCE362CA96F286D9AECC2921D8D7DB5C08 local:gutjnl;60/9/1189 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally. Contributors: TS, MBP, and CLS contributed equally to this work; RMP, PC, TLC, and KTW designed research; TS, MBP, CLS, BGS, MA, RC, LEB, LAS, AD, and JR-G performed research; TS, CLS, MBP, RMM, DAI, TLC, and KTW analysed data; TS and KTW wrote the manuscript. |
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I. Cancer risk and suspect environmental agents publication-title: J Natl Cancer Inst – volume: 56 start-page: 1279 year: 1996 ident: b10 article-title: Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa publication-title: Cancer Res – volume: 90 start-page: 831 year: 2010 ident: b6 article-title: Role of innate immunity in Helicobacter pylori-induced gastric malignancy publication-title: Physiol Rev – volume: 270 start-page: 17771 year: 1995 ident: b23 article-title: Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration publication-title: J Biol Chem – volume: 33 start-page: 429 year: 1992 ident: b13 article-title: Helicobacter pylori: the African enigma publication-title: Gut – volume: 109 start-page: 138 year: 2004 ident: b28 article-title: Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer publication-title: Int J Cancer – volume: 97 start-page: 2839 year: 2002 ident: b17 article-title: Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma? publication-title: Am J Gastroenterol – volume: 39 start-page: 443 year: 2008 ident: b20 article-title: Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia publication-title: Arch Med Res – volume: 54 start-page: 1536 year: 2005 ident: b27 article-title: Long term follow up of patients treated for Helicobacter pylori infection publication-title: Gut – volume: 32 start-page: 1792 year: 2004 ident: b35 article-title: MUSCLE: multiple sequence alignment with high accuracy and high throughput publication-title: Nucleic Acids Res – volume: 7 start-page: 191 year: 2006 ident: b33 article-title: Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island publication-title: BMC Genomics – volume: 48 start-page: 3554 year: 1988 ident: b4 article-title: A human model of gastric carcinogenesis publication-title: Cancer Res – volume: 36 start-page: 2597 year: 1998 ident: b24 article-title: Expanding allelic diversity of Helicobacter pylori vacA publication-title: J Clin Microbiol – volume: 24 start-page: 167 year: 2000 ident: b26 article-title: Gastric dysplasia: the Padova international classification publication-title: Am J Surg Pathol – volume: 8 start-page: 184 year: 2007 ident: b32 article-title: Ancestral European roots of Helicobacter pylori in India publication-title: BMC Genomics – volume: 299 start-page: 1582 year: 2003 ident: b34 article-title: Traces of human migrations in Helicobacter pylori populations publication-title: Science – volume: 61 start-page: 177 year: 1994 ident: b3 article-title: Infection with Helicobacter pylori publication-title: IARC Monogr Eval Carcinog Risks Hum – volume: 44 start-page: 297 year: 1970 article-title: Carcinoma and intestinal metaplasia of the stomach in Colombian migrants publication-title: J Natl Cancer Inst – volume: 8 start-page: 184 year: 2007 article-title: Ancestral European roots of Helicobacter pylori in India publication-title: BMC Genomics – volume: 109 start-page: 138 year: 2004 article-title: Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer publication-title: Int J Cancer – volume: 42 start-page: 351 year: 1998 article-title: Oxidative DNA damage accumulation in gastric carcinogenesis publication-title: Gut – volume: 54 start-page: 1536 year: 2005 article-title: Long term follow up of patients treated for Helicobacter pylori infection publication-title: Gut – volume: 135 start-page: 91 year: 2008 article-title: Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms publication-title: Gastroenterology – volume: 66 start-page: 2569 year: 1990 article-title: Helicobacter pylori and gastric carcinoma. Serum antibody prevalence in populations with contrasting cancer risks publication-title: Cancer – volume: 24 start-page: 1596 year: 2007 article-title: MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0 publication-title: Mol Biol Evol – volume: 36 start-page: 2597 year: 1998 article-title: Expanding allelic diversity of Helicobacter pylori vacA publication-title: J Clin Microbiol – volume: 50 start-page: 4737 year: 1990 article-title: Gastric precancerous process in a high risk population: cohort follow-up publication-title: Cancer Res – volume: 14 start-page: 1464 year: 2005 article-title: Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis publication-title: Cancer Epidemiol Biomarkers Prev – volume: 24 start-page: 167 year: 2000 article-title: Gastric dysplasia: the Padova international classification publication-title: Am J Surg Pathol – volume: 61 start-page: 177 year: 1994 article-title: Infection with Helicobacter pylori publication-title: IARC Monogr Eval Carcinog Risks Hum – volume: 94 start-page: 1680 year: 2002 article-title: Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma publication-title: J Natl Cancer Inst – volume: 57 start-page: 324 year: 1994 article-title: Intestinal metaplasia types and the risk of gastric cancer: a cohort study in Slovenia publication-title: Int J Cancer – volume: 32 start-page: 1792 year: 2004 article-title: MUSCLE: multiple sequence alignment with high accuracy and high throughput publication-title: Nucleic Acids Res – volume: 3 start-page: e3307 year: 2008 article-title: Amerindian Helicobacter pylori strains go extinct, as European strains expand their host range publication-title: PLoS One – volume: 39 start-page: 443 year: 2008 article-title: Plasma selenium measurements in subjects from areas with contrasting gastric cancer risks in Colombia publication-title: Arch Med Res – volume: 36 start-page: 2258 year: 1998 article-title: Variants of the 3′ region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases publication-title: J Clin Microbiol – volume: 7 start-page: 191 year: 2006 article-title: Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island publication-title: BMC Genomics – volume: 14 start-page: 1874 year: 2005 article-title: Trends in Helicobacter pylori infection and gastric cancer in Mexico publication-title: Cancer Epidemiol Biomarkers Prev – volume: 20 start-page: 1161 year: 1996 article-title: Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994 publication-title: Am J Surg Pathol – volume: 64 start-page: 8521 year: 2004 article-title: Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis publication-title: Cancer Res – volume: 1 start-page: 1311 year: 1984 article-title: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration publication-title: Lancet – volume: 345 start-page: 784 year: 2001 article-title: Helicobacter pylori infection and the development of gastric cancer publication-title: N Engl J Med – volume: 127 start-page: 2654 year: 2010 article-title: Gastric cancer occurrence in preneoplastic lesions: a long-term follow-up in a high-risk area in Spain publication-title: Int J Cancer – volume: 57 start-page: 1027 year: 1976 article-title: Gastric cancer in Colombia. III. Natural history of precursor lesions publication-title: J Natl Cancer Inst – volume: 57 start-page: 1015 year: 1976 article-title: Gastric cancer in Colombia. I. Cancer risk and suspect environmental agents publication-title: J Natl Cancer Inst – volume: 97 start-page: 2839 year: 2002 article-title: Virulence-associated genotypes of Helicobacter pylori: do they explain the African enigma? publication-title: Am J Gastroenterol – volume: 40 start-page: 650 year: 2008 article-title: OLGA staging for gastritis: a tutorial publication-title: Dig Liver Dis – volume: 90 start-page: 831 year: 2010 article-title: Role of innate immunity in Helicobacter pylori-induced gastric malignancy publication-title: Physiol Rev – volume: 15 start-page: 835 year: 2009 article-title: The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations publication-title: Clin Microbiol Infect – volume: 33 start-page: 429 year: 1992 article-title: Helicobacter pylori: the African enigma publication-title: Gut – volume: 299 start-page: 1582 year: 2003 article-title: Traces of human migrations in Helicobacter pylori populations publication-title: Science – volume: 111 start-page: 638 year: 1996 article-title: Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease publication-title: Gastroenterology – volume: 270 start-page: 17771 year: 1995 article-title: Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration publication-title: J Biol Chem – volume: 55 start-page: 2111 year: 1995 article-title: Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach publication-title: Cancer Res – volume: 39 start-page: 1360 year: 2008 article-title: Eosinophils and mast cells in chronic gastritis: possible implications in carcinogenesis publication-title: Hum Pathol – volume: 56 start-page: 1279 year: 1996 article-title: Increased oxidative DNA damage in Helicobacter pylori-infected human gastric mucosa publication-title: Cancer Res – volume: 48 start-page: 3554 year: 1988 article-title: A human model of gastric carcinogenesis publication-title: Cancer Res – volume: 174 start-page: 631 year: 1996 article-title: Multiple strain colonization and metronidazole resistance in Helicobacter pylori-infected patients: identification from sequential and multiple biopsy specimens publication-title: J Infect Dis – reference: 21610271 - Gut. 2012 Mar;61(3):469-70. doi: 10.1136/gutjnl-2011-300317. |
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| Snippet | Background and aimsHelicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of... Background and aims Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of... Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death... BACKGROUND AND AIMS: Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of... |
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| SubjectTerms | Adult Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Typing Techniques Biological and medical sciences Biopsy Cell Transformation, Neoplastic - genetics Chronic illnesses Coasts DNA Damage Endoscopy gastric atrophy Gastric cancer Gastric Mucosa - metabolism Gastric Mucosa - microbiology Gastric Mucosa - pathology gastritis Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - complications Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori Helicobacter pylori - classification Helicobacter pylori - genetics Helicobacter pylori - pathogenicity Helicobacter pylori infection Histopathology Human bacterial diseases Human subjects Humans Immunohistochemistry infection Infections Infectious diseases intestinal metaplasia Lesions Male Males Medical sciences Middle Aged Mountains multi-locus sequence typing Multilocus sequence typing Phylogeny Phylogeography Precancerous Conditions - genetics Precancerous Conditions - microbiology Precancerous Conditions - pathology Stomach Neoplasms - genetics Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumorigenesis Tumors Ulcers |
| Title | Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk |
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