F04 Linear mixed model for the age of onset prediction in huntington disease from a peruvian cohort

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 92; no. Suppl 1; p. A21
• Main Authors: Cubas-Montecino, Diana, Cornejo-Olivas, Mario, Mazzetti, Pilar, Véliz-Otani, Diego
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.09.2021
• Subjects: Accuracy; Age; Huntingtons disease; Regression analysis

BackgroundBased on heritability analyses, unidentified genetic modifiers explain up to 38% of the remaining genetic variance after accounting for the CAG repeat number. We hypothesized that pedigree information can harness unknown genetic modifiers to increase the accuracy of age of onset prediction...