Chemokine receptor CCR5 antagonist maraviroc: medicinal chemistry and clinical applications

• Published in: Current topics in medicinal chemistry Vol. 14; no. 13; p. 1504
• Main Authors: Xu, Guoyan G, Guo, Jia, Wu, Yuntao
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2014
• Subjects: CCR5 Receptor Antagonists - chemistry; CCR5 Receptor Antagonists - pharmacology; CCR5 Receptor Antagonists - therapeutic use; Cyclohexanes - chemistry; Cyclohexanes - pharmacology; Cyclohexanes - therapeutic use; Drug Discovery; HIV - drug effects; HIV - immunology; HIV - metabolism; HIV Infections - drug therapy; HIV Infections - metabolism; HIV Infections - virology; Humans; Maraviroc; Receptors, CCR5 - genetics; Receptors, CCR5 - immunology; Receptors, CCR5 - metabolism; Structure-Activity Relationship; Triazoles - chemistry; Triazoles - pharmacology; Triazoles - therapeutic use; Virus Replication - drug effects
• ISSN: 1873-4294
• DOI: 10.2174/1568026614666140827143745

The human immunodeficiency virus (HIV) causes acquired immumodeficiency syndrome (AIDS), one of the worst global pandemic. The virus infects human CD4 T cells and macrophages, and causes CD4 depletion. HIV enters target cells through the binding of the viral envelope glycoprotein to CD4 and the chem...