Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes

• Published in: BMC genomics Vol. 10; no. 1; p. 489
• Main Authors: Garrett, Matthew, Fullaondo, Ane, Troxler, Laurent, Micklem, Gos, Gubb, David
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 22.10.2009; BioMed Central; BMC
• Subjects: Amino Acid Sequence; Animals; Comparative Genomic Hybridization; Conservation; Conserved Sequence; Drosophila; Drosophila melanogaster; Drosophilidae - genetics; Evolution; Evolution, Molecular; Gene expression; Genetic aspects; Genome, Insect; Genomes; Homology; Insects; Molecular Sequence Data; Multigene Family; Proteinase inhibitors; Proteins; Sequence Alignment; Sequence Analysis, DNA; serpins; Serpins - genetics; Synteny; Wound healing; France; United Kingdom

The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase inhibitors. However, a substantial proportion (42%) lacks this motif and represents...