Canine distemper virus induces apoptosis in cervical tumor derived cell lines

• Published in: Virology journal Vol. 8; no. 1; p. 334
• Main Authors: Del Puerto, Helen L, Martins, Almir S, Milsted, Amy, Souza-Fagundes, Elaine M, Braz, Gissandra F, Hissa, Barbara, Andrade, Luciana O, Alves, Fabiana, Rajão, Daniela S, Leite, Rômulo C, Vasconcelos, Anilton C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.06.2011; BioMed Central; BMC
• Subjects: Apoptosis; cancer therapy; Canine distemper; Canine distemper virus; Canine morbillivirus; Caspase; Caspase 3 - biosynthesis; Caspase 8 - biosynthesis; caspase-3; caspase-8; Cell lines; cerebellum; Cervical cancer; Cervical tumor; Distemper Virus, Canine - pathogenicity; DNA Fragmentation; family; Flow Cytometry; gene expression; Gene Expression Profiling; HeLa cell; HeLa Cells; HPV; Humans; immunocytochemistry; Immunohistochemistry; Oncolytic Viruses - pathogenicity; Physiological aspects; quantitative polymerase chain reaction; tissue culture; uterine cervical neoplasms; viruses; Brazil

Apoptosis can be induced or inhibited by viral proteins, it can form part of the host defense against virus infection, or it can be a mechanism for viral spread to neighboring cells. Canine distemper virus (CDV) induces apoptotic cells in lymphoid tissues and in the cerebellum of dogs naturally infe...