The intracellular region of Notch ligands: does the tail make the difference?

• Published in: Biology direct Vol. 2; no. 1; p. 19
• Main Authors: Pintar, Alessandro, De Biasio, Alfredo, Popovic, Matija, Ivanova, Neli, Pongor, Sándor
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 10.07.2007; BioMed Central; BMC
• Subjects: Analysis; Cytoplasmic filaments; Genetic transcription; Ligand binding (Biochemistry); Methods; Morphogenesis; Review; Italy

The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role o...