Anatomy and evolution of telomeric and subtelomeric regions in the human protozoan parasite Trypanosoma cruzi

• Published in: BMC genomics Vol. 13; no. 1; p. 229
• Main Authors: Moraes Barros, Roberto R, Marini, Marjorie M, Antônio, Cristiane Regina, Cortez, Danielle R, Miyake, Andrea M, Lima, Fábio M, Ruiz, Jeronimo C, Bartholomeu, Daniella C, Chiurillo, Miguel A, Ramirez, José Luis, da Silveira, José Franco
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.06.2012; BioMed Central; BMC
• Subjects: Acyltransferases - genetics; Acyltransferases - metabolism; Analysis; Biotechnology; Chagas Disease - parasitology; Chromosomes; Chromosomes - chemistry; Chromosomes - genetics; Contig Mapping; Evolution, Molecular; Gene Frequency; Genes; Genetic aspects; Genetics; Genome, Protozoan; Genomics; Glycoproteins - genetics; Glycoproteins - metabolism; Humans; Molecular evolution; Neuraminidase - genetics; Neuraminidase - metabolism; Parasites; Physiological aspects; Proteins; Protozoa; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Relative abundance; Retroelements; RNA; RNA Helicases - genetics; RNA Helicases - metabolism; Telomere - chemistry; Telomere - genetics; Telomeres; Trypanosoma; Trypanosoma cruzi - genetics; Brazil; Venezuela
• ISSN: 1471-2164; 1471-2164
• DOI: 10.1186/1471-2164-13-229

The subtelomeres of many protozoa are highly enriched in genes with roles in niche adaptation. T. cruzi trypomastigotes express surface proteins from Trans-Sialidase (TS) and Dispersed Gene Family-1 (DGF-1) superfamilies which are implicated in host cell invasion. Single populations of T. cruzi may...