Prothrombotic gene variants as risk factors of acute myocardial infarction in young women
Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibri...
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Published in | Journal of translational medicine Vol. 10; no. 1; p. 235 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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BioMed Central Ltd
21.11.2012
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Abstract | Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age.
We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy).
In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05).
Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. |
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AbstractList | Doc number: 235 Abstract Background: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. Methods: We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). Results: In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Discussion and conclusion: Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. BACKGROUND: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. METHODS: We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). RESULTS: In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). DISCUSSION AND CONCLUSION: Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Abstract Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. Methods We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). Results In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Discussion and conclusion Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Abstract Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. Methods We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). Results In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Discussion and conclusion Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. BACKGROUNDAcute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. METHODSWe studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). RESULTSIn young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). DISCUSSION AND CONCLUSIONOur data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men. Prothrombotic gene variants could play a role as risk factors for AMI at young age. Methods We studied Factor V Leiden, FII G20210A, MTHFR C677T and beta-fibrinogen -455G>A variants by real-time PCR in 955 young AMI (362 females) and in 698 AMI (245 females) patients. The data were compared to those obtained in 909 unrelated subjects (458 females) from the general population of the same geographical area (southern Italy). Results In young AMI females, the allelic frequency of either FV Leiden and of FII G20210A was significantly higher versus the general population (O.R.: 3.67 for FV Leiden and O.R.: 3.84 for FII G20210A; p<0.001). Among AMI patients we showed only in males that the allelic frequency of the MTHFR C677T variant was significantly higher as compared to the general population. Such difference was due to a significantly higher frequency in AMI males of the MTHFR C677T variant homozygous genotype (O.R. 3.05). Discussion and conclusion Our data confirm that young AMI in females is a peculiar phenotype with specific risk factors as the increased plasma procoagulant activity of FV and FII. On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. The knowledge of such risk factors (that may be easily identified by molecular analysis) may help to improve prevention strategies for acute coronary diseases in specific risk-group subjects. Keywords: Young AMI, Gender, AMI, Gene variants, Mutations, Prothrombotic variants, Genetic predisposition |
ArticleNumber | 235 |
Audience | Academic |
Author | Di Fiore, Rosanna Averna, Maurizio R Noto, Davide Quaranta, Sandro Di Micco, Pierpaolo Ciaccio, Marcello Zarrilli, Federica Caruso, Antonietta Tomaiuolo, Rossella Bellia, Chiara Cefalù, Angelo B Castaldo, Giuseppe |
AuthorAffiliation | 4 Sezione di Biochimica Clinica e Medicina Molecolare, Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy 6 Pronto Soccorso, Unità di Medicina Interna, Ospedale Fatebenefratelli di Napoli, Naples, Italy 2 Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy 3 Facoltà di Scienze Biotecnologiche, Università di Napoli Federico II, Naples, Italy 7 Dipartimento di Bioscienze e Territorio, Università del Molise, Isernia, Italy 5 Centro per le Dislipidemie Genetiche-Dipartimento di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, Palermo, 90127, Italy 1 CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, Naples, 80145, Italy |
AuthorAffiliation_xml | – name: 2 Dipartimento di Biochimica e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy – name: 7 Dipartimento di Bioscienze e Territorio, Università del Molise, Isernia, Italy – name: 4 Sezione di Biochimica Clinica e Medicina Molecolare, Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy – name: 1 CEINGE-Biotecnologie Avanzate, Via Gaetano Salvatore 486, Naples, 80145, Italy – name: 5 Centro per le Dislipidemie Genetiche-Dipartimento di Medicina Interna e Specialistica, Università di Palermo, Via del Vespro 129, Palermo, 90127, Italy – name: 6 Pronto Soccorso, Unità di Medicina Interna, Ospedale Fatebenefratelli di Napoli, Naples, Italy – name: 3 Facoltà di Scienze Biotecnologiche, Università di Napoli Federico II, Naples, Italy |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23171482$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1111/j.1538-7836.2010.03982.x 10.1067/mhj.2002.120300 10.1161/01.CIR.0000051465.94572.D0 10.1007/s11568-008-9025-x 10.1161/CIRCULATIONAHA.107.187397 10.1016/j.clinbiochem.2012.02.024 10.1111/j.1474-9726.2012.00793.x 10.1016/j.amjcard.2004.06.051 10.1001/jama.288.16.2023 10.1016/S0140-6736(03)12516-0 10.1186/1479-5876-6-36 10.1373/clinchem.2006.071696 10.1161/01.CIR.95.8.2032 10.1093/ajcn/77.1.63 10.1161/hc5001.100793 10.1016/S0002-9343(99)00218-1 10.1056/NEJM199404143301503 10.1016/S0140-6736(10)60962-2 10.1016/S0140-6736(06)68263-9 10.1515/CCLM.2010.361 10.1161/01.ATV.0000222011.13026.25 |
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PublicationTitle | Journal of translational medicine |
PublicationTitleAlternate | J Transl Med |
PublicationYear | 2012 |
Publisher | BioMed Central Ltd BioMed Central BMC |
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References | 22239660 - Aging Cell. 2012 Jun;11(3):394-400 16503463 - Lancet. 2006 Feb 25;367(9511):651-8 12615788 - Circulation. 2003 Mar 4;107(8):1117-22 21034258 - Clin Chem Lab Med. 2010 Dec;48 Suppl 1:S41-51 21131039 - Lancet. 2010 Dec 11;376(9757):2032-9 16614319 - Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1405-12 11773912 - Am Heart J. 2002 Jan;143(1):56-62 9133512 - Circulation. 1997 Apr 15;95(8):2032-6 20626623 - J Thromb Haemost. 2010 Oct;8(10):2116-21 16873315 - Clin Chem. 2006 Aug;52(8):1625-7 12499324 - Am J Clin Nutr. 2003 Jan;77(1):63-70 12387655 - JAMA. 2002 Oct 23-30;288(16):2023-31 22425942 - Clin Biochem. 2012 Jun;45(9):637-40 10492319 - Am J Med. 1999 Sep;107(3):254-61 8127331 - N Engl J Med. 1994 Apr 14;330(15):1041-6 15476609 - Am J Cardiol. 2004 Oct 15;94(8):989-92 12598142 - Lancet. 2003 Feb 15;361(9357):567-71 17951284 - Circulation. 2007 Nov 27;116(22):2634-53 11748101 - Circulation. 2001 Dec 18;104(25):3063-8 18627609 - J Transl Med. 2008;6:36 18704761 - Genomic Med. 2008 Jan;2(1-2):7-22 Y Yamada (1367_CR12) 2008; 2 SM Boekholdt (1367_CR18) 2001; 104 S Kathiresan (1367_CR8) 2006; 26 R Tomaiuolo (1367_CR16) 2012; 11 Y Zheng (1367_CR9) 2006; 367 Atherosclerosis, Thrombosis and Vascular Biology Italian Study Group (1367_CR11) 2003; 107 ME Marenberg (1367_CR4) 1994; 330 O Scudiero (1367_CR15) 2006; 52 V Bafunno (1367_CR5) 2010; 48 JA Fournier (1367_CR3) 2004; 94 C Bellia (1367_CR17) 2012; 45 L Choudhury (1367_CR1) 1999; 107 M Doughty (1367_CR2) 2002; 143 K Thygesen (1367_CR14) 2007; 116 JPA Ioannidis (1367_CR13) 2003; 361 H Morita (1367_CR19) 1997; 95 R Meleady (1367_CR20) 2003; 77 PM Mannucci (1367_CR10) 2010; 8 PA Kyrle (1367_CR6) 2010; 376 P Di Micco (1367_CR7) 2008; 15 M Klerk (1367_CR21) 2002; 288 |
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Snippet | Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men.... Abstract Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly... Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men.... Doc number: 235 Abstract Background: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality... BACKGROUNDAcute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged men.... Background: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged... BACKGROUND: Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly aged... Abstract Background Acute myocardial infarction (AMI) in young women represent an extreme phenotype associated with a higher mortality compared with similarly... |
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SubjectTerms | Adult Aged AMI Comparative analysis Factor V Female Fibrin Fibrinogen Gender Gene Frequency - genetics Gene variants Genes Genetic predisposition Genetic Predisposition to Disease Genetic research Health aspects Heart attack Homozygote Humans Male Medical research Medicine, Experimental Mortality Mutations Myocardial Infarction - genetics Polymorphism, Single Nucleotide - genetics Prothrombin - genetics Prothrombotic variants Risk Factors Thrombosis - genetics Women Young AMI Young women |
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Title | Prothrombotic gene variants as risk factors of acute myocardial infarction in young women |
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