Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages

• Published in: BMC pulmonary medicine Vol. 14; no. 1; p. 152
• Main Authors: Juárez, Esmeralda, Carranza, Claudia, Hernández-Sánchez, Fernando, Loyola, Elva, Escobedo, Dante, León-Contreras, Juan Carlos, Hernández-Pando, Rogelio, Torres, Martha, Sada, Eduardo
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 25.09.2014; BioMed Central
• Subjects: Analysis; Antimicrobial agents; Autophagy; Autophagy - drug effects; Cells, Cultured; Chemokines; Colony Count, Microbial; Cytokines; Cytokines - metabolism; Diaminopimelic Acid - analogs & derivatives; Diaminopimelic Acid - pharmacology; Gene expression; GTP-Binding Proteins - metabolism; Humans; Immunity, Innate; Kinases; Ligands; Macrophages; Macrophages, Alveolar - drug effects; Macrophages, Alveolar - metabolism; Macrophages, Alveolar - microbiology; Microtubule-Associated Proteins - metabolism; Molecular biology; Monocytes - drug effects; Monocytes - metabolism; Monocytes - microbiology; Mortality; Mycobacterium tuberculosis; Mycobacterium tuberculosis - growth & development; Nod1 Signaling Adaptor Protein - metabolism; Oligopeptides - pharmacology; Physiological aspects; Proteins; Pulmonology; Streptococcus infections; Studies; Tuberculosis; Tuberculosis, Pulmonary - metabolism; Up-Regulation - drug effects

Nucleotide-binding oligomerizing domain-1 (NOD1) is a cytoplasmic receptor involved in recognizing bacterial peptidoglycan fragments that localize to the cytosol. NOD1 activation triggers inflammation, antimicrobial mechanisms and autophagy in both epithelial cells and murine macrophages. NOD1 media...