Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

• Published in: Journal of translational medicine Vol. 10; no. 1; p. 166
• Main Authors: Song, Zhenju, Yao, Chenling, Yin, Jun, Tong, Chaoyang, Zhu, Duming, Sun, Zhan, Jiang, Jinjun, Shao, Mian, Zhang, Yaping, Deng, Zhi, Tao, Zhengang, Sun, Si, Bai, Chunxue
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.08.2012; BioMed Central; BMC
• Subjects: Acute lung injury; Acute Lung Injury - complications; Acute Lung Injury - genetics; Acute respiratory distress syndrome; Analysis; Base Sequence; Case-Control Studies; Disease susceptibility; DNA Primers; Enzyme-Linked Immunosorbent Assay; Enzymes; Genes; Genetic aspects; Genetic research; Genetic Variation; Humans; Infection; Interleukins; Mortality; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Respiratory distress syndrome; RNA; Rodents; Sepsis - complications; Sepsis - genetics; Single nucleotide polymorphisms; Studies; TLR signaling pathway; TNF Receptor-Associated Factor 6 - genetics; TRAF6; Tumor necrosis factor; United Kingdom

Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR)-related pathway was important in the development of acute lung injury (ALI). The aim of this study was to determine whether common genetic variation in four genes of the TLR signaling pathway were...