(Im)Perfect robustness and adaptation of metabolic networks subject to metabolic and gene-expression regulation: marrying control engineering with metabolic control analysis

• Published in: BMC systems biology Vol. 7; no. 1; p. 131
• Main Authors: He, Fei, Fromion, Vincent, Westerhoff, Hans V
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.11.2013; BioMed Central
• Subjects: Adaptation; Adaptations; Adenosine Triphosphate - metabolism; Biodegradation; Biology; Cell metabolism; Computer Science; Control engineering; Engineering; Enzymes; Gene expression; Gene Expression Regulation; Gene Regulatory Networks; Genetic aspects; Genetic engineering; Intracellular Space - metabolism; Leucine - biosynthesis; Life Sciences; Mathematics; Metabolic Networks and Pathways; Metabolites; Methodology; Models, Biological; Physiological aspects; Signal transduction; Studies; France; United Kingdom; Netherlands; Control engineering; Synthetic biology; Robustness; Transcriptional regulation; Metabolic control analysis

Metabolic control analysis (MCA) and supply-demand theory have led to appreciable understanding of the systems properties of metabolic networks that are subject exclusively to metabolic regulation. Supply-demand theory has not yet considered gene-expression regulation explicitly whilst a variant of...