Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study

• Published in: BMC medical genetics Vol. 10; no. 33; p. 33
• Main Authors: Ezzidi, Intissar, Mtiraoui, Nabil, Cauchi, Stéphane, Vaillant, Emmanuel, Dechaume, Aurélie, Chaieb, Molka, Kacem, Maha, Almawi, Wassim Y, Froguel, Philippe, Mahjoub, Touhami, Vaxillaire, Martine
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.04.2009; BioMed Central; BMC
• Subjects: Aged; Alleles; Arabs - genetics; Case-Control Studies; Demographic aspects; Diabetes Mellitus, Type 2 - genetics; Female; Gene Frequency; Genetic aspects; Genome-Wide Association Study; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Single nucleotide polymorphisms; TCF Transcription Factors - genetics; Transcription Factor 7-Like 2 Protein; Tunisia; Type 2 diabetes; Tunisia

Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the contribution to T2D of five of these established T2D-associated loci...