The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis

• Published in: BMC infectious diseases Vol. 7; no. 1; p. 96
• Main Authors: Lala, Sanjay, Dheda, Keertan, Chang, Jung-Su, Huggett, Jim F, Kim, Louise U, Johnson, Margaret A, Rook, Graham A W, Keshav, Satish, Zumla, Alimuddin
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.08.2007; BioMed Central; BMC
• Subjects: Adolescent; Adult; Binding proteins; Bronchoalveolar Lavage Fluid - immunology; Control; Diagnosis; Female; Gene expression; Genetic aspects; Health aspects; Humans; Interleukin-4 - biosynthesis; Interleukin-4 - genetics; Interleukin-4 - immunology; Leukocytes - immunology; Leukocytes - metabolism; Leukocytes - physiology; Leukocytes, Mononuclear - immunology; Male; MAP Kinase Signaling System; Middle Aged; Mycobacterium tuberculosis - immunology; Nod2 Signaling Adaptor Protein - biosynthesis; Nod2 Signaling Adaptor Protein - genetics; Nod2 Signaling Adaptor Protein - immunology; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Toll-Like Receptor 2 - biosynthesis; Toll-Like Receptor 2 - genetics; Toll-Like Receptor 2 - immunology; Toll-Like Receptor 4 - biosynthesis; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - immunology; Transcription, Genetic; Tuberculosis; Tuberculosis, Pulmonary - genetics; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - metabolism; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - immunology; United Kingdom

NOD2, an intracellular pathogen recognition sensor, modulates innate defences to muropeptides derived from various bacterial species, including Mycobacterium tuberculosis (MTB). Experimentally, NOD2 attenuates two key putative mycobactericidal mechanisms. TNF-alpha synthesis is markedly reduced in M...