Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

• Published in: Respiratory research Vol. 14; no. 1; p. 13
• Main Authors: Freeman, Christine M, Martinez, Fernando J, Han, MeiLan K, Washko, George R, McCubbrey, Alexandra L, Chensue, Stephen W, Arenberg, Douglas A, Meldrum, Catherine A, McCloskey, Lisa, Curtis, Jeffrey L
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.02.2013; BioMed Central; BMC
• Subjects: Aged; Analysis; Bacteria; CCL3 protein; CD4 antigen; CD56 antigen; CD8 antigen; CD8+ T cells; CD8-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - microbiology; Cell culture; Cells; Cells, Cultured; Chronic obstructive pulmonary disease; Cytokines; Data processing; endopeptidase; FasL protein; Female; Gene Expression Regulation, Bacterial; granzyme B; Humans; Immune system; Immunology; Interleukin 13; Killer cells; Lung; Lung - cytology; Lung - metabolism; Lung - microbiology; Lung diseases, Obstructive; Lymphocytes T; Male; Middle Aged; Monocyte chemoattractant protein 1; Natural killer cells; Pathology; Perforin; Physiological aspects; Prospective Studies; Pulmonary Disease, Chronic Obstructive - metabolism; Pulmonary Disease, Chronic Obstructive - microbiology; Respiratory function; Serine proteinase; Smokers; T cell receptors; T cells; TLR1 protein; TLR2 protein; TLR3 protein; TLR4 protein; TLR5 protein; TLR9 protein; Toll-like receptors; Toll-Like Receptors - biosynthesis; Ann Arbor Michigan; United States > US

Toll-like receptors (TLRs) on T cells can modulate their responses, however, the extent and significance of TLR expression by lung T cells, NK cells, or NKT cells in chronic obstructive pulmonary disease (COPD) is unknown. Lung tissue collected from clinically-indicated resections (n = 34) was used...