Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma

• Published in: Journal of neuroinflammation Vol. 8; no. 1; p. 32
• Main Authors: Tafani, Marco, Di Vito, Maura, Frati, Alessandro, Pellegrini, Laura, De Santis, Elena, Sette, Giovanni, Eramo, Adriana, Sale, Patrizio, Mari, Emanuela, Santoro, Antonio, Raco, Antonino, Salvati, Maurizio, De Maria, Ruggero, Russo, Matteo A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 13.04.2011; BioMed Central; BMC
• Subjects: Brain - anatomy & histology; Brain - metabolism; Brain - pathology; Brain Mapping - methods; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Cell Hypoxia; Cell Movement - physiology; Diagnosis; Gene Expression; Genetic aspects; Glioblastoma - genetics; Glioblastoma - pathology; Glioblastoma multiforme; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Inflammation - genetics; Inflammation - pathology; Magnetic resonance imaging; Neoplasm Invasiveness; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; NF-kappa B - genetics; NF-kappa B - metabolism; Physiological aspects; Stem cells; Tumor Cells, Cultured; Tumor Microenvironment; Italy

Adaptation to hypoxia and consequent pro-inflammatory gene expression of prostate and breast carcinomas have been implicated in the progression toward cancer malignant phenotype. Only partial data are available for the human tumor glioblastoma multiforme (GBM). The aim of our study was to analyze th...