An immunohistochemical study of the localization and developmental expression of ghrelin and its functional receptor in the ovine placenta

• Published in: Reproductive biology and endocrinology Vol. 5; no. 1; p. 25
• Main Authors: Harrison, Joanne L, Adam, Clare L, Brown, Yvonne A, Wallace, Jacqueline M, Aitken, Raymond P, Lea, Richard G, Miller, David W
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.06.2007; BioMed Central; BMC
• Subjects: Animals; Antibody Specificity; Female; Gestational Age; Ghrelin; Hormone receptors; Immunohistochemistry; Organ Size; Peptide Hormones - immunology; Peptide Hormones - metabolism; Physiological aspects; Placenta; Placenta - anatomy & histology; Placenta - metabolism; Placentation; Pregnancy; Properties; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Receptors, Ghrelin; Sheep; Australia; United Kingdom

Ghrelin is an orexigenic hormone principally produced by the stomach, but also by numerous peripheral tissues including the placenta. Ghrelin acts via growth hormone secretagogue receptors (GHSR-1a) to alter food intake, fat utilization, and cellular proliferation, and has been suggested to play a r...