Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study

• Published in: Molecular cancer Vol. 7; no. 1; p. 68
• Main Authors: Brim, Hassan, Mokarram, Pooneh, Naghibalhossaini, Fakhraddin, Saberi-Firoozi, Mehdi, Al-Mandhari, Mansour, Al-Mawaly, Kamla, Al-Mjeni, Rayhaneh, Al-Sayegh, Abeer, Raeburn, Sandy, Lee, Edward, Giardiello, Francis, Smoot, Duane T, Vilkin, Alexander, Boland, C Richard, Goel, Ajay, Hafezi, Mitra, Nouraie, Mehdi, Ashktorab, Hassan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.08.2008; BioMed Central; BMC
• Subjects: Adaptor Proteins, Signal Transducing - genetics; African Americans; Aged; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Complications and side effects; Diagnosis; Female; Gene mutations; Genetic aspects; Genetics, Population; Humans; Iran; Male; Microsatellite Instability; Multivariate Analysis; MutL Protein Homolog 1; Nuclear Proteins - genetics; Oman; Physiological aspects; Proto-Oncogene Proteins B-raf - genetics; Risk factors; Satellite DNA; United States

We have identified an alternative pathway of tumorigenesis in sporadic colon cancer, involving microsatellite instability due to mismatched repair methylation, which may be driven by mutations in the BRAF gene (V600E). Colorectal cancer (CRC) is the most common cancer in the world, and African Ameri...