Significance of CD133 expression in esophageal squamous cell carcinoma

• Published in: World journal of surgical oncology Vol. 11; no. 1; p. 51
• Main Authors: Okamoto, Hiroshi, Fujishima, Fumiyoshi, Nakamura, Yasuhiro, Zuguchi, Masashi, Ozawa, Yohei, Takahashi, Yayoi, Miyata, Go, Kamei, Takashi, Nakano, Toru, Taniyama, Yusuke, Teshima, Jin, Watanabe, Mika, Sato, Akira, Ohuchi, Noriaki, Sasano, Hironobu
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01.03.2013; BioMed Central
• Subjects: AC133 Antigen; Adult; Aged; Aged, 80 and over; Analysis; Antigens, CD - metabolism; Biomarkers, Tumor - metabolism; Breast cancer; Cancer; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - therapy; Cell cycle; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Dissection; Epidermal growth factor; Esophageal cancer; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - mortality; Esophageal Neoplasms - therapy; Female; Follow-Up Studies; Glycoproteins; Glycoproteins - metabolism; Hospitals; Humans; Immunoenzyme Techniques; Immunohistochemistry; Lymphatic Metastasis; Male; Measurement; Middle Aged; Mortality; Multivariate analysis; Neoplasm Staging; Oncology, Experimental; Ostomy; Pathology; Peptides - metabolism; Physiological aspects; Prognosis; Proteins; Proto-Oncogene Proteins c-mdm2 - metabolism; Receptor, Epidermal Growth Factor - metabolism; Squamous cell carcinoma; Stem cells; Survival Rate; Tumor markers; Tumor proteins; Tumors; Japan

CD133 was recently reported to be a cancer stem cell marker and a prognostic marker for several tumors. However, few studies have investigated CD133 expression in esophageal squamous cell carcinoma (ESCC). Therefore, we examined whether CD133 could serve as a prognostic marker of ESCC and investigat...