Posterolateral inter-transverse lumbar fusion in a mouse model

• Published in: Journal of orthopaedic surgery and research Vol. 8; no. 1; p. 2
• Main Authors: Bobyn, Justin, Rasch, Anton, Little, David G, Schindeler, Aaron
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.01.2013; BioMed Central; BMC
• Subjects: Animals; Arthrodesis; BMP; Bone Morphogenetic Protein 2 - administration & dosage; Bone Morphogenetic Protein 2 - therapeutic use; Bones; Collagen; Comparative analysis; Density; Dose-Response Relationship, Drug; Female; Fusion; Genetically modified organisms; Humans; Intraoperative Period; Lumbar Vertebrae - anatomy & histology; Lumbar Vertebrae - diagnostic imaging; Lumbar Vertebrae - physiology; Lumbar Vertebrae - surgery; Male; Mice; Mice, Inbred C57BL; Models, Animal; Mouse; Orthopedics; Osteogenesis - drug effects; Recombinant Proteins - administration & dosage; Recombinant Proteins - therapeutic use; Species Specificity; Spinal Fusion - adverse effects; Spinal Fusion - methods; Spine; Surgery; Surgical techniques; Technical Note; Transforming Growth Factor beta - administration & dosage; Transforming Growth Factor beta - therapeutic use; Treatment Outcome; Vertebrae; X-Ray Microtomography - methods

Spinal fusion is a common orthopaedic procedure that has been previously modeled using canine, lapine, and rodent subjects. Despite the increasing availability of genetically modified mouse strains, murine models have only been infrequently described. To present an efficient and minimally traumatic...