Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

• Published in: Molecular cancer Vol. 9; no. 1; p. 8
• Main Authors: Oyesanya, Regina A, Greenbaum, Susie, Dang, David, Lee, Zendra, Mukherjee, Abir, Wu, Jinhua, Dent, Paul, Fang, Xianjun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.01.2010; BioMed Central; BMC
• Subjects: Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Cellular signal transduction; Epidermal Growth Factor - pharmacology; ErbB Receptors - metabolism; Female; G proteins; Genetic aspects; GTP-Binding Proteins - metabolism; Hepatocyte Growth Factor - pharmacology; Humans; Interleukin-8 - biosynthesis; Lysophospholipids - pharmacology; Neoplasm Invasiveness; NF-kappa B - metabolism; Phosphotyrosine - metabolism; Physiological aspects; Transcription Factor AP-1 - metabolism; Transcription factors; United States

The role of the epidermal growth factor receptor (EGFR) and other receptor tyrosine kinases (RTKs) in provoking biological actions of G protein-coupled receptors (GPCRs) has been one of the most disputed subjects in the field of GPCR signal transduction. The purpose of the current study is to identi...