X chromosome aneuploidy in the Alzheimer’s disease brain

• Published in: Molecular cytogenetics Vol. 7; no. 1; p. 20
• Main Authors: Yurov, Yuri B, Vorsanova, Svetlana G, Liehr, Thomas, Kolotii, Alexei D, Iourov, Ivan Y
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.03.2014; BioMed Central
• Subjects: Advertising executives; Aging; Alzheimer's disease; Analysis; Brain research; Cell cycle; Cell division; Chromosomes; Complications and side effects; Confidence intervals; Cytogenetics; Deoxyribonucleic acid; Diagnosis; DNA; Genetics; Medical research; Neurodegeneration; Pathology; Risk factors

Although the link between brain aging and Alzheimer's disease (AD) is a matter of debate, processes hallmarking cellular and tissue senescence have been repeatedly associated with its pathogenesis. Here, we have studied X chromosome aneuploidy (a recognized feature of aged cell populations) in...