N-end rule and retroviral infection: no effect on integrase

• Published in: Virology journal Vol. 10; no. 1; p. 233
• Main Authors: Boso, Guney, Tasaki, Takafumi, Tae Kwon, Yong, Somia, Nikunj V
• Format: Journal Article
• Language: English
• Published: England Springer-Verlag 13.07.2013; BioMed Central Ltd; BioMed Central
• Subjects: amino acids; Animals; Cancer; Cell Line; DNA; Enzymes; fibroblasts; Genetic aspects; Genomes; half life; HIV Integrase - genetics; HIV Integrase - metabolism; HIV-1 - physiology; Human immunodeficiency virus 1; Humans; Mammals; Mice; Microtubule-Associated Proteins - metabolism; Mutant Proteins - genetics; Mutant Proteins - metabolism; mutants; pathogenicity; Physiological aspects; Proteins; proteolysis; quantitative polymerase chain reaction; Retrovirus; Retrovirus infections; Reverse Transcription; Risk factors; Sequence Deletion; Ubiquitin; ubiquitin-protein ligase; Ubiquitin-Protein Ligases - metabolism; Viral infections; Virus Integration; United States

BACKGROUND: Integration of double stranded viral DNA is a key step in the retroviral life cycle. Virally encoded enzyme, integrase, plays a central role in this reaction. Mature forms of integrase of several retroviruses (i.e. HIV-1 and MLV) bear conserved destabilizing N-terminal residues of the N-...