Modeling RNA interference in mammalian cells

• Published in: BMC systems biology Vol. 5; no. 1; p. 19
• Main Authors: Cuccato, Giulia, Polynikis, Athanasios, Siciliano, Velia, Graziano, Mafalda, di Bernardo, Mario, di Bernardo, Diego
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.01.2011; BioMed Central
• Subjects: Animals; Cells; CHO Cells; Colleges & universities; Cricetinae; Cricetulus; Enzymes - metabolism; Experimental data; Experiments; Genetic algorithms; Genetic aspects; HEK293 Cells; Humans; Mammals; Mathematical models; Messenger RNA; Models, Genetic; Physiological aspects; Ribonucleic acid; RNA; RNA Interference; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; United Kingdom; Italy

RNA interference (RNAi) is a regulatory cellular process that controls post-transcriptional gene silencing. During RNAi double-stranded RNA (dsRNA) induces sequence-specific degradation of homologous mRNA via the generation of smaller dsRNA oligomers of length between 21-23nt (siRNAs). siRNAs are th...