Multinational evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis: integrating systematic literature research and expert opinion of a broad international panel of rheumatologists in the 3E Initiative
Objective To develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA). Methods 697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008–9 consisting of three separate ro...
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Published in | Annals of the Rheumatic Diseases Vol. 70; no. 1; pp. 15 - 24 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article Book Review Conference Proceeding |
Language | English |
Published |
London
BMJ Publishing Group Ltd and European League Against Rheumatism
01.01.2011
BMJ Publishing Group BMJ Publishing Group LTD BMJ Group |
Subjects | |
Online Access | Get full text |
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Summary: | Objective To develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA). Methods 697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008–9 consisting of three separate rounds of discussions and modified Delphi votes. In the first round 10 clinical questions were selected. A bibliographic team systematically searched Medline, Embase, the Cochrane Library and ACR/EULAR 2007–2008 meeting abstracts. Relevant articles were reviewed for quality assessment, data extraction and synthesis. In the second round each country elaborated a set of national recommendations. Finally, multinational recommendations were formulated and agreement among the participants and the potential impact on their clinical practice was assessed. Results A total of 39 756 references were identified, of which 250 were systematically reviewed. Ten multinational key recommendations about the investigation and follow-up of UPIA were formulated. One recommendation addressed differential diagnosis and investigations prior to establishing the operational diagnosis of UPIA, seven recommendations related to the diagnostic and prognostic value of clinical and laboratory assessments in established UPIA (history and physical examination, acute phase reactants, autoantibodies, radiographs, MRI and ultrasound, genetic markers and synovial biopsy), one recommendation highlighted predictors of persistence (chronicity) and the final recommendation addressed monitoring of clinical disease activity in UPIA. Conclusions Ten recommendations on how to investigate and follow-up UPIA in the clinical setting were developed. They are evidence-based and supported by a large panel of rheumatologists, thus enhancing their validity and practical use. |
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Bibliography: | ark:/67375/NVC-4VP8V5SX-1 PM, IC, WK, RK, BK, MS, LS-F, KT, WV and EV contributed equally to this work. href:annrheumdis-70-15.pdf istex:BA8C4C68B48B042461BBE213F8057DC7B073EE12 ArticleID:annrheumdis130625 PMID:20724311 local:annrheumdis;70/1/15 ObjectType-Article-1 ObjectType-Instructional Material/Guideline-2 ObjectType-Feature-3 SourceType-Conference Papers & Proceedings-1 ObjectType-News-4 ObjectType-Conference-5 content type line 25 |
ISSN: | 0003-4967 1468-2060 1468-2060 |
DOI: | 10.1136/ard.2010.130625 |