Panax notoginseng Saponins Promote Cell Death and Chemosensitivity in Pancreatic Cancer through the Apoptosis and Autophagy Pathways

• Published in: Anti-cancer agents in medicinal chemistry Vol. 21; no. 13; p. 1680
• Main Authors: Yao, Li-Chao, Wu, Lun, Wang, Wei, Zhai, Lu-Lu, Ye, Lin, Xiang, Feng, Tang, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2021
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; Apoptosis - drug effects; Cell Death - drug effects; Cell Proliferation - drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Panax notoginseng - chemistry; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Tumor Cells, Cultured; Panax notoginseng saponins; apoptosis; pancreatic cancer; gemcitabine; autophagy; chemosensitivity

Panax notoginseng Saponins (PNS) is used as a traditional Chinese medicine for ischemic stroke and cardiovascular disease; it has been proven to possess anticancer activity recently. In this study, we aimed to explore the curative anticancer effect and potential mechanisms of PNS in pancreatic cance...