Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients. Protocol Version 9, 19 February 2007 known as SIGNET (Scottish Intensive care Glutamine or seleNium Evaluative Trial)

• Published in: Current controlled trials in cardiovascular medicine Vol. 8; no. 1; p. 25
• Main Authors: Andrews, Peter J D, Avenell, Alison, Noble, David W, Campbell, Marion K, Battison, Claire G, Croal, Bernard L, Simpson, William G, Norrie, John, Vale, Luke D, Cook, Jonathon, de Verteuil, Robyn, Milne, Anne C
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 20.09.2007; BioMed Central; BMC
• Subjects: Amino acids; Antibiotics; Care and treatment; Critically ill; Free radicals; Glutamine; Hospitals; Illnesses; Immune system; Infections; Intensive care; Length of stay; Liver; Metabolism; Mortality; Nutrition; Parenteral nutrition; Patients; Selenium; Study Protocol; Systematic review; United Kingdom; United Kingdom > UK

Mortality rates in the Intensive Care Unit and subsequent hospital mortality rates in the UK remain high. Infections in Intensive Care are associated with a 2-3 times increased risk of death. It is thought that under conditions of severe metabolic stress glutamine becomes "conditionally essenti...